3ORQ
Crystal Structure of N5-Carboxyaminoimidazole synthetase from Staphylococcus aureus complexed with ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0034028 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 375 |
| Chain | Residue |
| A | GLU254 |
| A | GLU267 |
| A | ADP376 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP A 376 |
| Chain | Residue |
| A | GLU183 |
| A | LYS184 |
| A | TYR185 |
| A | LEU186 |
| A | ILE188 |
| A | GLU191 |
| A | HIS214 |
| A | GLU254 |
| A | PHE256 |
| A | ASN266 |
| A | GLU267 |
| A | MG375 |
| A | HOH423 |
| A | ARG108 |
| A | LYS148 |
| A | TYR154 |
| A | ASP155 |
| A | GLY156 |
| A | GLN159 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE POP A 377 |
| Chain | Residue |
| A | TYR154 |
| A | LYS340 |
| A | ARG347 |
| A | HOH450 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADP B 375 |
| Chain | Residue |
| B | LYS148 |
| B | GLU183 |
| B | LYS184 |
| B | TYR185 |
| B | LEU186 |
| B | GLU254 |
| B | ASN266 |
| B | GLU267 |
| B | MG376 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 376 |
| Chain | Residue |
| B | GLU191 |
| B | HIS214 |
| B | ADP375 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 377 |
| Chain | Residue |
| B | GLY18 |
| B | GLN19 |
| B | LEU20 |
| B | GLU77 |
| B | PHE78 |
| B | POP378 |
| B | HOH455 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE POP B 378 |
| Chain | Residue |
| B | GLN19 |
| B | LYS340 |
| B | ARG347 |
| B | LYS348 |
| B | GOL377 |
