3OOW
Octameric structure of the phosphoribosylaminoimidazole carboxylase catalytic subunit from Francisella tularensis subsp. tularensis SCHU S4.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0006164 | biological_process | purine nucleotide biosynthetic process |
| E | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0006164 | biological_process | purine nucleotide biosynthetic process |
| F | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0006164 | biological_process | purine nucleotide biosynthetic process |
| G | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0016853 | molecular_function | isomerase activity |
| G | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0006164 | biological_process | purine nucleotide biosynthetic process |
| H | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0016853 | molecular_function | isomerase activity |
| H | 0034023 | molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | HIS70 |
| A | LEU71 |
| A | HOH182 |
| A | HOH203 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 165 |
| Chain | Residue |
| A | THR42 |
| A | ASP44 |
| A | LYS45 |
| A | HOH250 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 166 |
| Chain | Residue |
| A | HIS40 |
| A | ARG41 |
| A | PO4167 |
| A | HOH182 |
| A | HOH311 |
| A | HOH531 |
| G | PRO106 |
| A | SER38 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 167 |
| Chain | Residue |
| A | GLY10 |
| A | SER11 |
| A | ASP14 |
| A | ALA65 |
| A | GLY66 |
| A | PO4166 |
| A | HOH203 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 168 |
| Chain | Residue |
| A | GLU51 |
| A | LYS78 |
| A | HOH465 |
| D | LYS141 |
| G | ASP44 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 169 |
| Chain | Residue |
| A | ASN94 |
| B | ASN94 |
| C | ASN94 |
| F | ASN94 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT A 170 |
| Chain | Residue |
| A | GLY117 |
| A | MSE118 |
| A | HOH175 |
| A | HOH534 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 164 |
| Chain | Residue |
| B | THR42 |
| B | ASP44 |
| B | LYS45 |
| B | HOH205 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 165 |
| Chain | Residue |
| A | ASN138 |
| B | GLY29 |
| B | ASP136 |
| B | ASN138 |
| B | ILE139 |
| B | HOH193 |
| B | HOH294 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 166 |
| Chain | Residue |
| B | SER38 |
| B | HIS40 |
| B | ARG41 |
| B | FMT168 |
| B | HOH183 |
| B | HOH206 |
| D | PRO106 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT B 167 |
| Chain | Residue |
| B | THR52 |
| B | ARG56 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 168 |
| Chain | Residue |
| B | SER11 |
| B | ASP14 |
| B | ALA65 |
| B | GLY66 |
| B | PO4166 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT B 169 |
| Chain | Residue |
| B | MSE118 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 164 |
| Chain | Residue |
| C | HIS70 |
| C | LEU71 |
| C | HOH187 |
| C | HOH192 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 165 |
| Chain | Residue |
| C | THR42 |
| C | ASP44 |
| C | LYS45 |
| C | HOH301 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD C 166 |
| Chain | Residue |
| B | GLN96 |
| C | GLN96 |
| C | HOH526 |
| D | GLN96 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 C 167 |
| Chain | Residue |
| C | GLY10 |
| C | SER38 |
| C | HIS40 |
| C | ARG41 |
| C | PO4168 |
| C | HOH187 |
| C | HOH207 |
| C | HOH335 |
| H | PRO106 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 168 |
| Chain | Residue |
| C | GLY10 |
| C | SER11 |
| C | ASP14 |
| C | ALA65 |
| C | GLY66 |
| C | PO4167 |
| C | HOH192 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT C 169 |
| Chain | Residue |
| C | MSE118 |
| C | HOH177 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 164 |
| Chain | Residue |
| D | HIS70 |
| D | LEU71 |
| D | HOH172 |
| D | HOH202 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 165 |
| Chain | Residue |
| E | HOH302 |
| D | THR42 |
| D | ASP44 |
| D | LYS45 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD D 166 |
| Chain | Residue |
| B | GLN96 |
| D | GLN96 |
| D | HOH515 |
| D | HOH528 |
| E | GLN96 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 167 |
| Chain | Residue |
| B | PRO106 |
| D | GLY10 |
| D | SER38 |
| D | HIS40 |
| D | ARG41 |
| D | PO4168 |
| D | HOH172 |
| D | HOH399 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 D 168 |
| Chain | Residue |
| B | PRO106 |
| D | GLY10 |
| D | SER11 |
| D | ASP14 |
| D | ALA65 |
| D | GLY66 |
| D | PO4167 |
| D | HOH202 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT D 169 |
| Chain | Residue |
| D | GLY117 |
| D | MSE118 |
| D | HOH188 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL E 164 |
| Chain | Residue |
| E | HIS40 |
| E | HIS70 |
| E | LEU71 |
| E | HOH196 |
| E | HOH383 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL E 165 |
| Chain | Residue |
| E | THR42 |
| E | ASP44 |
| E | LYS45 |
| E | HOH257 |
| E | HOH478 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 166 |
| Chain | Residue |
| E | GLY10 |
| E | SER11 |
| E | ASP14 |
| E | ALA65 |
| E | GLY66 |
| E | PO4167 |
| E | HOH383 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 167 |
| Chain | Residue |
| E | SER38 |
| E | HIS40 |
| E | ARG41 |
| E | PO4166 |
| E | HOH196 |
| E | HOH289 |
| F | PRO106 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT E 168 |
| Chain | Residue |
| E | MSE118 |
| E | HOH183 |
| E | HOH509 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT E 169 |
| Chain | Residue |
| E | ASN94 |
| H | ASN94 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL F 164 |
| Chain | Residue |
| F | HIS40 |
| F | HIS70 |
| F | LEU71 |
| F | HOH174 |
| F | HOH221 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL F 165 |
| Chain | Residue |
| F | THR42 |
| F | ASP44 |
| F | LYS45 |
| F | HOH286 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD F 166 |
| Chain | Residue |
| F | GLN96 |
| F | HOH527 |
| G | GLN96 |
| G | LEU100 |
| site_id | DC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 F 167 |
| Chain | Residue |
| E | PRO106 |
| F | GLY10 |
| F | SER38 |
| F | HIS40 |
| F | ARG41 |
| F | PO4168 |
| F | HOH174 |
| F | HOH342 |
| site_id | DC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 F 168 |
| Chain | Residue |
| F | GLY10 |
| F | SER11 |
| F | ASP14 |
| F | ALA65 |
| F | GLY66 |
| F | PO4167 |
| F | HOH221 |
| site_id | EC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT F 169 |
| Chain | Residue |
| F | GLY117 |
| F | MSE118 |
| F | HOH184 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL G 164 |
| Chain | Residue |
| G | HIS70 |
| G | LEU71 |
| G | HOH178 |
| G | HOH191 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD G 165 |
| Chain | Residue |
| C | HOH530 |
| G | GLN96 |
| G | HOH529 |
| H | GLN96 |
| site_id | EC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 G 166 |
| Chain | Residue |
| A | PRO106 |
| G | GLY10 |
| G | SER11 |
| G | ASP14 |
| G | ALA65 |
| G | GLY66 |
| G | PO4167 |
| G | HOH178 |
| site_id | EC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 G 167 |
| Chain | Residue |
| A | PRO106 |
| G | SER38 |
| G | HIS40 |
| G | ARG41 |
| G | PO4166 |
| G | HOH169 |
| G | HOH191 |
| G | HOH541 |
| site_id | EC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT G 168 |
| Chain | Residue |
| G | MSE118 |
| G | HOH186 |
| G | HOH188 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL H 164 |
| Chain | Residue |
| H | HIS70 |
| H | LEU71 |
| H | HOH191 |
| H | HOH262 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL H 165 |
| Chain | Residue |
| H | THR42 |
| H | ASP44 |
| H | LYS45 |
| H | HOH194 |
| H | HOH475 |
| site_id | EC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 H 166 |
| Chain | Residue |
| H | GLY10 |
| H | SER11 |
| H | ASP14 |
| H | ALA65 |
| H | GLY66 |
| H | PO4167 |
| H | HOH262 |
| site_id | FC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 H 167 |
| Chain | Residue |
| C | PRO106 |
| H | SER38 |
| H | HIS40 |
| H | ARG41 |
| H | PO4166 |
| H | HOH191 |
| H | HOH351 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT H 168 |
| Chain | Residue |
| H | MSE118 |
| H | HOH179 |
| H | HOH188 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FMT H 169 |
| Chain | Residue |
| H | GLY29 |
