3OOE
Crystal structure of E. Coli purine nucleoside phosphorylase with PO4
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006974 | biological_process | DNA damage response |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0019686 | biological_process | purine nucleoside interconversion |
A | 0042278 | biological_process | purine nucleoside metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0047975 | molecular_function | guanosine phosphorylase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006152 | biological_process | purine nucleoside catabolic process |
B | 0006974 | biological_process | DNA damage response |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0019686 | biological_process | purine nucleoside interconversion |
B | 0042278 | biological_process | purine nucleoside metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0047975 | molecular_function | guanosine phosphorylase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006152 | biological_process | purine nucleoside catabolic process |
C | 0006974 | biological_process | DNA damage response |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0016020 | cellular_component | membrane |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0019686 | biological_process | purine nucleoside interconversion |
C | 0042278 | biological_process | purine nucleoside metabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0047975 | molecular_function | guanosine phosphorylase activity |
D | 0003824 | molecular_function | catalytic activity |
D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
D | 0006152 | biological_process | purine nucleoside catabolic process |
D | 0006974 | biological_process | DNA damage response |
D | 0009116 | biological_process | nucleoside metabolic process |
D | 0009164 | biological_process | nucleoside catabolic process |
D | 0016020 | cellular_component | membrane |
D | 0016757 | molecular_function | glycosyltransferase activity |
D | 0016763 | molecular_function | pentosyltransferase activity |
D | 0019686 | biological_process | purine nucleoside interconversion |
D | 0042278 | biological_process | purine nucleoside metabolic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0047975 | molecular_function | guanosine phosphorylase activity |
E | 0003824 | molecular_function | catalytic activity |
E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
E | 0006152 | biological_process | purine nucleoside catabolic process |
E | 0006974 | biological_process | DNA damage response |
E | 0009116 | biological_process | nucleoside metabolic process |
E | 0009164 | biological_process | nucleoside catabolic process |
E | 0016020 | cellular_component | membrane |
E | 0016757 | molecular_function | glycosyltransferase activity |
E | 0016763 | molecular_function | pentosyltransferase activity |
E | 0019686 | biological_process | purine nucleoside interconversion |
E | 0042278 | biological_process | purine nucleoside metabolic process |
E | 0042802 | molecular_function | identical protein binding |
E | 0047975 | molecular_function | guanosine phosphorylase activity |
F | 0003824 | molecular_function | catalytic activity |
F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
F | 0006152 | biological_process | purine nucleoside catabolic process |
F | 0006974 | biological_process | DNA damage response |
F | 0009116 | biological_process | nucleoside metabolic process |
F | 0009164 | biological_process | nucleoside catabolic process |
F | 0016020 | cellular_component | membrane |
F | 0016757 | molecular_function | glycosyltransferase activity |
F | 0016763 | molecular_function | pentosyltransferase activity |
F | 0019686 | biological_process | purine nucleoside interconversion |
F | 0042278 | biological_process | purine nucleoside metabolic process |
F | 0042802 | molecular_function | identical protein binding |
F | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 A 238 |
Chain | Residue |
A | GLY20 |
A | ARG24 |
A | ARG87 |
A | GLY89 |
A | SER90 |
A | HOH266 |
A | HOH791 |
D | ARG43 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 A 239 |
Chain | Residue |
A | ALA214 |
A | ALA215 |
A | HOH616 |
A | HOH624 |
A | HOH796 |
A | HOH1099 |
F | ASN222 |
F | HOH279 |
A | THR213 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 A 240 |
Chain | Residue |
A | HIS97 |
D | HIS97 |
D | ARG149 |
site_id | AC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 B 238 |
Chain | Residue |
B | GLY20 |
B | ARG87 |
B | GLY89 |
B | SER90 |
B | HOH286 |
B | HOH508 |
B | HOH1082 |
E | ARG43 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 B 239 |
Chain | Residue |
B | ARG207 |
B | HIS209 |
B | THR219 |
B | ASN222 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 B 240 |
Chain | Residue |
B | PRO96 |
B | HIS97 |
B | HOH914 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 C 238 |
Chain | Residue |
C | GLY20 |
C | ARG87 |
C | GLY89 |
C | SER90 |
C | HOH363 |
C | HOH484 |
F | ARG43 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 D 238 |
Chain | Residue |
A | ARG43 |
D | GLY20 |
D | ARG87 |
D | GLY89 |
D | SER90 |
D | HOH506 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 E 238 |
Chain | Residue |
B | ARG43 |
E | GLY20 |
E | ARG87 |
E | GLY89 |
E | SER90 |
E | HOH265 |
E | HOH505 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 E 239 |
Chain | Residue |
E | THR220 |
E | ASN222 |
E | ASP223 |
E | HOH949 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 E 240 |
Chain | Residue |
E | ARG101 |
E | THR220 |
E | PHE221 |
E | HOH949 |
E | HOH1039 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 F 238 |
Chain | Residue |
C | ARG43 |
F | GLY20 |
F | ARG24 |
F | ARG87 |
F | GLY89 |
F | SER90 |
F | HOH289 |
F | HOH298 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 F 239 |
Chain | Residue |
A | ASN222 |
A | HOH374 |
A | HOH399 |
F | THR213 |
F | ALA214 |
F | ALA215 |
F | HOH510 |
F | HOH698 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PO4 F 240 |
Chain | Residue |
F | LEU95 |
F | PRO96 |
F | HIS97 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIytkEL |
Chain | Residue | Details |
A | GLY61-LEU76 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | ASP204 | |
B | ASP204 | |
C | ASP204 | |
D | ASP204 | |
E | ASP204 | |
F | ASP204 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | HIS4 | |
B | HIS4 | |
C | HIS4 | |
D | HIS4 | |
E | HIS4 | |
F | HIS4 |
site_id | SWS_FT_FI3 |
Number of Residues | 18 |
Details | BINDING: in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | GLY20 | |
D | GLY20 | |
D | ARG24 | |
D | ARG87 | |
E | GLY20 | |
E | ARG24 | |
E | ARG87 | |
F | GLY20 | |
F | ARG24 | |
F | ARG87 | |
A | ARG24 | |
A | ARG87 | |
B | GLY20 | |
B | ARG24 | |
B | ARG87 | |
C | GLY20 | |
C | ARG24 | |
C | ARG87 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | ARG43 | |
B | ARG43 | |
C | ARG43 | |
D | ARG43 | |
E | ARG43 | |
F | ARG43 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: in other chain => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | GLU179 | |
E | SER203 | |
F | GLU179 | |
F | SER203 | |
A | SER203 | |
B | GLU179 | |
B | SER203 | |
C | GLU179 | |
C | SER203 | |
D | GLU179 | |
D | SER203 | |
E | GLU179 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | ARG217 | |
B | ARG217 | |
C | ARG217 | |
D | ARG217 | |
E | ARG217 | |
F | ARG217 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | LYS26 | |
B | LYS26 | |
C | LYS26 | |
D | LYS26 | |
E | LYS26 | |
F | LYS26 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
A | GLY20 | electrostatic stabiliser |
A | ARG24 | electrostatic stabiliser |
A | ARG43 | electrostatic stabiliser |
A | ARG87 | electrostatic stabiliser |
A | SER90 | electrostatic stabiliser |
A | ASP204 | proton shuttle (general acid/base) |
A | ARG217 | enhance reactivity |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
B | GLY20 | electrostatic stabiliser |
B | ARG24 | electrostatic stabiliser |
B | ARG43 | electrostatic stabiliser |
B | ARG87 | electrostatic stabiliser |
B | SER90 | electrostatic stabiliser |
B | ASP204 | proton shuttle (general acid/base) |
B | ARG217 | enhance reactivity |
site_id | MCSA3 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
C | GLY20 | electrostatic stabiliser |
C | ARG24 | electrostatic stabiliser |
C | ARG43 | electrostatic stabiliser |
C | ARG87 | electrostatic stabiliser |
C | SER90 | electrostatic stabiliser |
C | ASP204 | proton shuttle (general acid/base) |
C | ARG217 | enhance reactivity |
site_id | MCSA4 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
D | GLY20 | electrostatic stabiliser |
D | ARG24 | electrostatic stabiliser |
D | ARG43 | electrostatic stabiliser |
D | ARG87 | electrostatic stabiliser |
D | SER90 | electrostatic stabiliser |
D | ASP204 | proton shuttle (general acid/base) |
D | ARG217 | enhance reactivity |
site_id | MCSA5 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
E | GLY20 | electrostatic stabiliser |
E | ARG24 | electrostatic stabiliser |
E | ARG43 | electrostatic stabiliser |
E | ARG87 | electrostatic stabiliser |
E | SER90 | electrostatic stabiliser |
E | ASP204 | proton shuttle (general acid/base) |
E | ARG217 | enhance reactivity |
site_id | MCSA6 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
F | GLY20 | electrostatic stabiliser |
F | ARG24 | electrostatic stabiliser |
F | ARG43 | electrostatic stabiliser |
F | ARG87 | electrostatic stabiliser |
F | SER90 | electrostatic stabiliser |
F | ASP204 | proton shuttle (general acid/base) |
F | ARG217 | enhance reactivity |