Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OM3

Catalytic core subunits (I and II) of cytochrome C oxidase from Rhodobacter sphaeroides with K362M mutation in the reduced state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0006811	biological_process	monoatomic ion transport
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0022904	biological_process	respiratory electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005886	cellular_component	plasma membrane
C	0006119	biological_process	oxidative phosphorylation
C	0006811	biological_process	monoatomic ion transport
C	0009060	biological_process	aerobic respiration
C	0015990	biological_process	electron transport coupled proton transport
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0004129	molecular_function	cytochrome-c oxidase activity
D	0005507	molecular_function	copper ion binding
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0022900	biological_process	electron transport chain
D	0022904	biological_process	respiratory electron transport chain
D	0042773	biological_process	ATP synthesis coupled electron transport
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMU A 1005

Chain	Residue
A	MET56
A	GLN61
A	PHE62
A	PHE502
A	TRD552
A	HOH619

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMU A 7

Chain	Residue
A	HOH561
A	LEU34
A	MET443
A	SER444

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD A 1013

Chain	Residue
A	TYR50
A	SER79

site_id	AC4
Number of Residues	28
Details	BINDING SITE FOR RESIDUE HEA A 1

Chain	Residue
A	LEU34
A	VAL45
A	THR48
A	MET51
A	ARG52
A	TRP95
A	ILE99
A	HIS102
A	MET106
A	MET107
A	VAL111
A	GLY171
A	TRP172
A	TYR414
A	PHE420
A	HIS421
A	SER425
A	VAL429
A	ILE432
A	MET460
A	PHE468
A	GLN471
A	ARG481
A	ARG482
A	SER504
A	HOH587
A	HOH589
A	HOH626

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEA A 2

Chain	Residue
A	HOH15
A	TRP172
A	VAL287
A	VAL291
A	HIS333
A	HIS334
A	THR352
A	ALA356
A	GLY360
A	GLY395
A	VAL396
A	GLY398
A	LEU401
A	SER402
A	ASP407
A	HIS411
A	VAL416
A	HIS419
A	PHE420
A	VAL423
A	MET424
A	ARG481
A	HOH559
A	HOH596

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD A 552

Chain	Residue
A	TRP81
A	DMU1005

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TRD A 3

Chain	Residue
A	PHE469
A	ARG476
B	THR41

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU1 A 5

Chain	Residue
A	HIS284
A	HIS333
A	HIS334

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 6

Chain	Residue
A	HIS411
A	ASP412
B	GLU254
B	HOH503
B	HOH766
B	HOH769

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 553

Chain	Residue
A	GLU54
A	ALA57
A	GLY59
A	GLN61
A	HOH613
A	HOH619

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DMU B 1

Chain	Residue
A	TRP451
A	PHE510
A	GLY513
A	HOH586
B	DMU2
B	HOH26
B	GLN142
B	TRP143
B	PRO164
B	HOH403
B	HOH712
B	HOH759

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMU B 2

Chain	Residue
A	TRP451
A	HOH584
B	DMU1

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DMU B 3

Chain	Residue
A	TRP371
B	PHE71
B	LEU75
B	HIS96
B	ASN97
B	TRP104
C	GLU86
D	SER173
D	PRO174
D	GLU177

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMU B 6

Chain	Residue
B	PRO121
B	GLU128
B	HOH493

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD B 4

Chain	Residue
A	MET353
B	ALA117

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE HTH B 286

Chain	Residue
B	GLU152
B	ALA276
B	GLU280
B	HIS283
B	HOH709
D	ALA276
D	GLU280
D	HIS283

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU1 B 287

Chain	Residue
B	CYS252
B	GLU254
B	CYS256
B	HIS260
B	CU1288

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU1 B 288

Chain	Residue
B	HIS217
B	CYS252
B	CYS256
B	MET263
B	CU1287

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 8

Chain	Residue
B	GLU280
B	HIS283
B	HIS285
D	GLU152

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD B 9

Chain	Residue
B	HIS96
B	GLU101
B	HOH708
B	HOH741
B	HOH742

site_id	CC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMU C 10

Chain	Residue
C	MET56
C	GLN61
C	PHE62
C	SER83
C	ALA84
C	VAL85
C	PHE502
C	TRD552
C	HOH573

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMU C 5

Chain	Residue
C	TRP451

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMU C 9

Chain	Residue
C	MET443

site_id	CC6
Number of Residues	28
Details	BINDING SITE FOR RESIDUE HEA C 1

Chain	Residue
C	LEU34
C	GLY38
C	VAL45
C	THR48
C	MET51
C	ARG52
C	TRP95
C	ILE99
C	HIS102
C	MET106
C	MET107
C	VAL111
C	GLY171
C	TRP172
C	TYR414
C	PHE420
C	HIS421
C	MET424
C	SER425
C	VAL429
C	PHE468
C	GLN471
C	ARG481
C	ARG482
C	SER504
C	PHE508
C	HOH555
C	HOH575

site_id	CC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEA C 2

Chain	Residue
C	HOH15
C	TRP172
C	TRP280
C	VAL287
C	VAL291
C	HIS333
C	HIS334
C	GLY360
C	PHE391
C	GLY395
C	VAL396
C	GLY398
C	ILE399
C	LEU401
C	SER402
C	ASP407
C	HIS411
C	VAL416
C	HIS419
C	PHE420
C	VAL423
C	MET424
C	ARG481
C	HOH577
D	PRO108

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TRD C 552

Chain	Residue
C	DMU10
C	TRP81
C	PRO82

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE TRD C 3

Chain	Residue
C	ARG476
D	THR41

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU1 C 553

Chain	Residue
C	HIS284
C	HIS333
C	HIS334

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 6

Chain	Residue
C	HIS411
C	ASP412
C	HOH564
C	HOH568
D	GLU254
D	HOH304

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 7

Chain	Residue
C	GLU54
C	ALA57
C	GLY59
C	GLN61
C	HOH565
C	HOH573

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMU D 4

Chain	Residue
D	LEU120
D	PRO121
D	ASN125
D	GLU128

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMU D 8

Chain	Residue
D	HIS96
D	ASN97

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU1 D 3

Chain	Residue
D	CYS252
D	GLU254
D	CYS256
D	HIS260
D	CU1286

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU1 D 286

Chain	Residue
D	CU13
D	HIS217
D	CYS252
D	CYS256
D	MET263

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 287

Chain	Residue
B	GLU152
D	GLU280
D	HIS283
D	HIS285

site_id	DC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD D 9

Chain	Residue
D	HIS96
D	GLU101

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiivlpafgivshviatfakkpifgylpmvyamvaigvlgfvvwa..HH

Chain	Residue	Details
A	TRP280-HIS334

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswtvpafgvkqdavpgrlaqlwfraeregiffgq......CselCgisHayM

Chain	Residue	Details
B	VAL215-MET263

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)