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3OLH

Human 3-mercaptopyruvate sulfurtransferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000098biological_processsulfur amino acid catabolic process
A0001822biological_processkidney development
A0001889biological_processliver development
A0004792molecular_functionthiosulfate sulfurtransferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0009440biological_processcyanate catabolic process
A0009636biological_processresponse to toxic substance
A0016740molecular_functiontransferase activity
A0016783molecular_functionsulfurtransferase activity
A0016784molecular_function3-mercaptopyruvate sulfurtransferase activity
A0019346biological_processtranssulfuration
A0021510biological_processspinal cord development
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0045202cellular_componentsynapse
A0070062cellular_componentextracellular exosome
A0070814biological_processhydrogen sulfide biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 290
ChainResidue
ASER66
AASP67
AARG68
APRO77
AGLY78
AHIS81

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 291
ChainResidue
AGLY249
ASER250
AGLY251
AVAL252
ATHR253
AHOH293
ATYR108
AARG197
ACYS248

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE NA A 292
ChainResidue
AARG68

Functional Information from PROSITE/UniProt
site_idPS00380
Number of Residues12
DetailsRHODANESE_1 Rhodanese signature 1. FeerHIPGAafF
ChainResidueDetails
APHE49-PHE60

site_idPS00683
Number of Residues11
DetailsRHODANESE_2 Rhodanese C-terminal signature. VpiYDGSWvEW
ChainResidueDetails
AVAL269-TRP279

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Cysteine persulfide intermediate => ECO:0000255|PROSITE-ProRule:PRU00173
ChainResidueDetails
ACYS248

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG188

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER35

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99J99
ChainResidueDetails
ALYS40

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99J99
ChainResidueDetails
ALYS146
ALYS164

226707

PDB entries from 2024-10-30

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