3OKR

Structure of Mtb apo 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0002135	molecular_function	CTP binding
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0008270	molecular_function	zinc ion binding
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0030145	molecular_function	manganese ion binding
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
A	0070567	molecular_function	cytidylyltransferase activity
B	0000287	molecular_function	magnesium ion binding
B	0002135	molecular_function	CTP binding
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0008270	molecular_function	zinc ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0030145	molecular_function	manganese ion binding
B	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
B	0070567	molecular_function	cytidylyltransferase activity
C	0000287	molecular_function	magnesium ion binding
C	0002135	molecular_function	CTP binding
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0008270	molecular_function	zinc ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0030145	molecular_function	manganese ion binding
C	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
C	0070567	molecular_function	cytidylyltransferase activity
D	0000287	molecular_function	magnesium ion binding
D	0002135	molecular_function	CTP binding
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0008270	molecular_function	zinc ion binding
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016779	molecular_function	nucleotidyltransferase activity
D	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
D	0030145	molecular_function	manganese ion binding
D	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D	0051484	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process
D	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR

Chain	Residue	Details
A	VAL103-ARG110

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00108

Chain	Residue	Details
A	ARG20
A	LYS27
B	ARG20
B	LYS27
C	ARG20
C	LYS27
D	ARG20
D	LYS27

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Positions MEP for the nucleophilic attack => ECO:0000255|HAMAP-Rule:MF_00108

Chain	Residue	Details
A	ARG157
A	LYS215
B	ARG157
B	LYS215
C	ARG157
C	LYS215
D	ARG157
D	LYS215

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