3OKF
2.5 Angstrom Resolution Crystal Structure of 3-Dehydroquinate Synthase (aroB) from Vibrio cholerae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003856 | molecular_function | 3-dehydroquinate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD A 367 |
| Chain | Residue |
| A | ASN46 |
| A | VAL110 |
| A | ASP113 |
| A | THR133 |
| A | THR134 |
| A | LEU136 |
| A | ASP140 |
| A | SER141 |
| A | LYS146 |
| A | LYS155 |
| A | ASN156 |
| A | THR48 |
| A | CYS173 |
| A | THR176 |
| A | LEU177 |
| A | GLU181 |
| A | PO4370 |
| A | HOH382 |
| A | HOH404 |
| A | HOH435 |
| A | HOH449 |
| A | HOH454 |
| A | VAL49 |
| A | TYR53 |
| A | ASP75 |
| A | GLU77 |
| A | LYS80 |
| A | GLY108 |
| A | GLY109 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 368 |
| Chain | Residue |
| A | LYS146 |
| A | ASN156 |
| B | ARG124 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 369 |
| Chain | Residue |
| A | ARG124 |
| B | LYS146 |
| B | ASN156 |
| B | PO4368 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 370 |
| Chain | Residue |
| A | LYS146 |
| A | LYS230 |
| A | ARG244 |
| A | LEU247 |
| A | NAD367 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 371 |
| Chain | Residue |
| A | GLN284 |
| A | ALA291 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 372 |
| Chain | Residue |
| A | HIS255 |
| A | LYS327 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 373 |
| Chain | Residue |
| A | LEU70 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 375 |
| Chain | Residue |
| A | LEU288 |
| A | LEU288 |
| A | THR340 |
| A | THR340 |
| A | HOH381 |
| A | HOH381 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD B 367 |
| Chain | Residue |
| B | ASN46 |
| B | THR48 |
| B | VAL49 |
| B | TYR53 |
| B | ASP75 |
| B | GLU77 |
| B | LYS80 |
| B | GLY108 |
| B | GLY109 |
| B | VAL110 |
| B | ASP113 |
| B | THR133 |
| B | THR134 |
| B | LEU136 |
| B | ASP140 |
| B | LYS146 |
| B | LYS155 |
| B | ASN156 |
| B | CYS173 |
| B | THR176 |
| B | LEU177 |
| B | HOH387 |
| B | HOH404 |
| B | HOH409 |
| B | HOH449 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 368 |
| Chain | Residue |
| A | PO4369 |
| B | LYS146 |
| B | LYS230 |
| B | ARG244 |
| B | LEU247 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 369 |
| Chain | Residue |
| B | GLU77 |
| B | GLN78 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 371 |
| Chain | Residue |
| B | HOH448 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2010","submissionDatabase":"PDB data bank","title":"2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (aroB) from Vibrio cholerae.","authors":["Minasov G.","Light S.H.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"PDB","id":"3OKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00110","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"AUG-2010","submissionDatabase":"PDB data bank","title":"2.5 angstrom resolution crystal structure of 3-dehydroquinate synthase (aroB) from Vibrio cholerae.","authors":["Minasov G.","Light S.H.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"PDB","id":"3OKF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00110","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
