Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE G52 A 401 |
| Chain | Residue |
| A | ARG8 |
| A | ILE50 |
| A | PRO81 |
| A | VAL82 |
| A | ILE84 |
| A | HOH1001 |
| A | HOH1026 |
| A | HOH1122 |
| A | HOH1123 |
| A | HOH1160 |
| B | ARG108 |
| A | ASP25 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | VAL132 |
| B | GLY148 |
| B | GLY149 |
| B | ILE150 |
| B | PRO181 |
| A | GLY27 |
| B | VAL182 |
| B | ILE184 |
| B | CL514 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | ASP60 |
| A | HOH1107 |
| A | HOH1108 |
| A | HOH1170 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 512 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 516 |
| Chain | Residue |
| A | THR74 |
| A | ASN88 |
| A | HOH1016 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | TRP42 |
| A | LYS55 |
| A | ARG57 |
| A | HOH1151 |
| A | HOH1152 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 501 |
| Chain | Residue |
| B | ASP160 |
| B | HOH1002 |
| B | HOH1003 |
| B | HOH1004 |
| B | HOH1005 |
| B | HOH1006 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 511 |
| Chain | Residue |
| A | ARG41 |
| B | THR174 |
| B | ASN188 |
| B | HOH1145 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 513 |
| Chain | Residue |
| B | GLN118 |
| B | SER137 |
| B | HOH1072 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 514 |
| Chain | Residue |
| A | G52401 |
| B | ILE147 |
| B | GLY148 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 515 |
| Chain | Residue |
| B | LYS120 |
| B | GLU121 |
| B | GLU134 |
| B | ASN183 |
| B | HOH1095 |
| B | HOH1175 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 602 |
| Chain | Residue |
| A | ILE54 |
| A | PRO79 |
| B | THR104 |
| B | TRP106 |
| B | ILE150 |
| B | GLY151 |
| B | HOH1098 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12924029","evidenceCode":"ECO:0000269"}]} |
