Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OJ6

Crystal structure of Blasticidin S Deaminase from Coccidioides Immitis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0009972	biological_process	cytidine deamination
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0047711	molecular_function	blasticidin-S deaminase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072527	biological_process	pyrimidine-containing compound metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0009972	biological_process	cytidine deamination
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0047711	molecular_function	blasticidin-S deaminase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072527	biological_process	pyrimidine-containing compound metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008270	molecular_function	zinc ion binding
C	0009972	biological_process	cytidine deamination
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0047711	molecular_function	blasticidin-S deaminase activity
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0072527	biological_process	pyrimidine-containing compound metabolic process
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008270	molecular_function	zinc ion binding
D	0009972	biological_process	cytidine deamination
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0047711	molecular_function	blasticidin-S deaminase activity
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0072527	biological_process	pyrimidine-containing compound metabolic process
D	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 150

Chain	Residue
A	CYS57
A	CYS91
A	CYS94
A	EDO151

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 150

Chain	Residue
B	CYS57
B	CYS91
B	CYS94
B	EDO151

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 150

Chain	Residue
C	CYS91
C	CYS94
C	EDO151
C	CYS57

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 150

Chain	Residue
D	CYS57
D	CYS91
D	CYS94
D	EDO151

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CL C 138

Chain	Residue
A	ASN53
A	GLY54
A	ARG93
B	ASN53
B	ARG93
C	ASN53
C	GLY54
C	ARG93
D	ASN53
D	ARG93

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 151

Chain	Residue
A	VAL32
A	CYS57
A	GLU59
A	ALA79
A	PRO90
A	CYS91
A	CYS94
A	HOH145
A	ZN150

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO B 151

Chain	Residue
B	VAL32
B	CYS57
B	GLU59
B	ALA79
B	PRO90
B	CYS91
B	CYS94
B	ZN150
B	HOH243

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO C 151

Chain	Residue
C	VAL32
C	CYS57
C	GLU59
C	ALA79
C	PRO90
C	CYS91
C	CYS94
C	ZN150
C	HOH154

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO D 151

Chain	Residue
D	VAL32
D	CYS57
D	GLU59
D	ALA79
D	SER89
D	PRO90
D	CYS91
D	CYS94
D	HOH141
D	ZN150

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 152

Chain	Residue
D	VAL43
D	PHE44
D	SER45
D	VAL65
D	HOH383

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	42
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. CAElvVLgvaaaagatklthivaianegrgils.......PCgr......CrqvL

Chain	Residue	Details
A	CYS57-LEU98

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	GLU59
B	GLU59
C	GLU59
D	GLU59

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: in other chain => ECO:0000250

Chain	Residue	Details
A	SER31
D	SER31
D	ARG85
D	TRP130
A	ARG85
A	TRP130
B	SER31
B	ARG85
B	TRP130
C	SER31
C	ARG85
C	TRP130

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	CYS57
D	CYS57
D	CYS91
D	CYS94
A	CYS91
A	CYS94
B	CYS57
B	CYS91
B	CYS94
C	CYS57
C	CYS91
C	CYS94

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	TYR128
B	TYR128
C	TYR128
D	TYR128

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)