3OIX
Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006222 | biological_process | UMP biosynthetic process |
| C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| D | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006222 | biological_process | UMP biosynthetic process |
| D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN A 400 |
| Chain | Residue |
| A | ALA20 |
| A | ILE193 |
| A | ASN194 |
| A | GLY219 |
| A | GLY220 |
| A | THR247 |
| A | GLY248 |
| A | GLY249 |
| A | GLY270 |
| A | THR271 |
| A | HOH312 |
| A | ALA21 |
| A | HOH313 |
| A | HOH326 |
| A | HOH331 |
| A | HOH341 |
| A | HOH487 |
| A | GLY22 |
| A | THR46 |
| A | TYR60 |
| A | ASN69 |
| A | MET71 |
| A | ASN128 |
| A | LYS165 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 500 |
| Chain | Residue |
| A | TYR142 |
| A | PHE144 |
| A | HIS174 |
| A | HOH335 |
| A | HOH360 |
| B | HIS174 |
| B | HOH370 |
| B | GOL500 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE FMN B 400 |
| Chain | Residue |
| B | ALA20 |
| B | ALA21 |
| B | GLY22 |
| B | THR46 |
| B | TYR60 |
| B | ASN69 |
| B | MET71 |
| B | ASN128 |
| B | LYS165 |
| B | ILE193 |
| B | ASN194 |
| B | GLY219 |
| B | GLY220 |
| B | THR247 |
| B | GLY248 |
| B | GLY249 |
| B | GLY270 |
| B | THR271 |
| B | HOH323 |
| B | HOH347 |
| B | HOH474 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 500 |
| Chain | Residue |
| A | HIS174 |
| A | GOL500 |
| B | TYR142 |
| B | PHE144 |
| B | HIS174 |
| B | HOH315 |
| B | HOH370 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE FMN C 400 |
| Chain | Residue |
| C | ALA20 |
| C | ALA21 |
| C | GLY22 |
| C | THR46 |
| C | TYR60 |
| C | ASN69 |
| C | MET71 |
| C | ASN128 |
| C | LYS165 |
| C | ILE193 |
| C | ASN194 |
| C | GLY219 |
| C | GLY220 |
| C | THR247 |
| C | GLY248 |
| C | GLY249 |
| C | GLY270 |
| C | THR271 |
| C | HOH316 |
| C | HOH319 |
| C | HOH329 |
| C | HOH330 |
| C | HOH337 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 500 |
| Chain | Residue |
| C | TYR142 |
| C | PHE144 |
| C | HIS174 |
| C | HOH379 |
| C | HOH398 |
| C | HOH414 |
| D | HIS174 |
| D | GOL500 |
| site_id | AC7 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE FMN D 400 |
| Chain | Residue |
| D | LYS165 |
| D | ILE193 |
| D | ASN194 |
| D | GLY219 |
| D | GLY220 |
| D | THR247 |
| D | GLY248 |
| D | GLY249 |
| D | GLY270 |
| D | THR271 |
| D | HOH312 |
| D | HOH323 |
| D | HOH379 |
| D | ALA20 |
| D | ALA21 |
| D | GLY22 |
| D | THR46 |
| D | TYR60 |
| D | ASN69 |
| D | MET71 |
| D | ASN128 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 500 |
| Chain | Residue |
| C | HIS174 |
| C | GOL500 |
| D | TYR142 |
| D | PHE144 |
| D | HIS174 |
| D | HOH314 |
Functional Information from PROSITE/UniProt
| site_id | PS00912 |
| Number of Residues | 21 |
| Details | DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGtGGVkTgrdAfeHIlCGA |
| Chain | Residue | Details |
| A | ILE244-ALA264 |
