3OIX

Crystal structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006222	biological_process	UMP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
B	0000166	molecular_function	nucleotide binding
B	0004152	molecular_function	dihydroorotate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006222	biological_process	UMP biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
C	0000166	molecular_function	nucleotide binding
C	0004152	molecular_function	dihydroorotate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006222	biological_process	UMP biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity
D	0000166	molecular_function	nucleotide binding
D	0004152	molecular_function	dihydroorotate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006222	biological_process	UMP biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	1990663	molecular_function	dihydroorotate dehydrogenase (fumarate) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FMN A 400

Chain	Residue
A	ALA20
A	ILE193
A	ASN194
A	GLY219
A	GLY220
A	THR247
A	GLY248
A	GLY249
A	GLY270
A	THR271
A	HOH312
A	ALA21
A	HOH313
A	HOH326
A	HOH331
A	HOH341
A	HOH487
A	GLY22
A	THR46
A	TYR60
A	ASN69
A	MET71
A	ASN128
A	LYS165

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 500

Chain	Residue
A	TYR142
A	PHE144
A	HIS174
A	HOH335
A	HOH360
B	HIS174
B	HOH370
B	GOL500

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN B 400

Chain	Residue
B	ALA20
B	ALA21
B	GLY22
B	THR46
B	TYR60
B	ASN69
B	MET71
B	ASN128
B	LYS165
B	ILE193
B	ASN194
B	GLY219
B	GLY220
B	THR247
B	GLY248
B	GLY249
B	GLY270
B	THR271
B	HOH323
B	HOH347
B	HOH474

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 500

Chain	Residue
A	HIS174
A	GOL500
B	TYR142
B	PHE144
B	HIS174
B	HOH315
B	HOH370

---

site_id	AC5
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FMN C 400

Chain	Residue
C	ALA20
C	ALA21
C	GLY22
C	THR46
C	TYR60
C	ASN69
C	MET71
C	ASN128
C	LYS165
C	ILE193
C	ASN194
C	GLY219
C	GLY220
C	THR247
C	GLY248
C	GLY249
C	GLY270
C	THR271
C	HOH316
C	HOH319
C	HOH329
C	HOH330
C	HOH337

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 500

Chain	Residue
C	TYR142
C	PHE144
C	HIS174
C	HOH379
C	HOH398
C	HOH414
D	HIS174
D	GOL500

---

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN D 400

Chain	Residue
D	LYS165
D	ILE193
D	ASN194
D	GLY219
D	GLY220
D	THR247
D	GLY248
D	GLY249
D	GLY270
D	THR271
D	HOH312
D	HOH323
D	HOH379
D	ALA20
D	ALA21
D	GLY22
D	THR46
D	TYR60
D	ASN69
D	MET71
D	ASN128

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 500

Chain	Residue
C	HIS174
C	GOL500
D	TYR142
D	PHE144
D	HIS174
D	HOH314

---

Functional Information from PROSITE/UniProt

site_id	PS00912
Number of Residues	21
Details	DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGtGGVkTgrdAfeHIlCGA

Chain	Residue	Details
A	ILE244-ALA264

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