3OIF
Crystal Structure of Enoyl-ACP Reductases I (FabI) from B. subtilis (complex with NAD and TCL)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0070417 | biological_process | cellular response to cold |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0070417 | biological_process | cellular response to cold |
| C | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006631 | biological_process | fatty acid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0030497 | biological_process | fatty acid elongation |
| C | 0070417 | biological_process | cellular response to cold |
| D | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006631 | biological_process | fatty acid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0030497 | biological_process | fatty acid elongation |
| D | 0070417 | biological_process | cellular response to cold |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD A 501 |
| Chain | Residue |
| A | GLY14 |
| A | VAL68 |
| A | CYS94 |
| A | ILE95 |
| A | ALA96 |
| A | LEU146 |
| A | THR147 |
| A | TYR148 |
| A | LYS165 |
| A | ALA191 |
| A | PRO193 |
| A | VAL15 |
| A | ILE194 |
| A | THR196 |
| A | LEU197 |
| A | SER198 |
| A | HOH298 |
| A | TCL502 |
| A | ALA16 |
| A | SER20 |
| A | ILE21 |
| A | ALA41 |
| A | LEU45 |
| A | CYS66 |
| A | ASP67 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TCL A 502 |
| Chain | Residue |
| A | ALA96 |
| A | ALA98 |
| A | TYR148 |
| A | TYR158 |
| A | MET161 |
| A | SER198 |
| A | ILE202 |
| A | NAD501 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD D 601 |
| Chain | Residue |
| D | GLY14 |
| D | VAL15 |
| D | SER20 |
| D | ILE21 |
| D | ALA41 |
| D | LEU45 |
| D | CYS66 |
| D | ASP67 |
| D | VAL68 |
| D | THR69 |
| D | CYS94 |
| D | ILE95 |
| D | ALA96 |
| D | LEU146 |
| D | THR147 |
| D | TYR148 |
| D | LYS165 |
| D | ALA191 |
| D | GLY192 |
| D | PRO193 |
| D | ILE194 |
| D | THR196 |
| D | LEU197 |
| D | SER198 |
| D | HOH290 |
| D | HOH294 |
| D | TCL602 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL D 602 |
| Chain | Residue |
| D | ALA96 |
| D | ALA98 |
| D | TYR148 |
| D | TYR158 |
| D | MET161 |
| D | SER198 |
| D | NAD601 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21185310","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Involved in acyl-ACP binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
