3ODA

Human PARP-1 zinc finger 1 (Zn1) bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0008270	molecular_function	zinc ion binding
D	0003677	molecular_function	DNA binding
D	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0008270	molecular_function	zinc ion binding
F	0003677	molecular_function	DNA binding
F	0008270	molecular_function	zinc ion binding
G	0003677	molecular_function	DNA binding
G	0008270	molecular_function	zinc ion binding
H	0003677	molecular_function	DNA binding
H	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 200

Chain	Residue
A	CYS21
A	CYS24
A	HIS53
A	CYS56

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 200

Chain	Residue
B	CYS21
B	CYS24
B	HIS53
B	CYS56

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 200

Chain	Residue
C	CYS24
C	HIS53
C	CYS56
C	CYS21

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 200

Chain	Residue
D	CYS21
D	CYS24
D	HIS53
D	CYS56

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 200

Chain	Residue
E	CYS21
E	CYS24
E	HIS53
E	CYS56

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 200

Chain	Residue
F	CYS21
F	CYS24
F	HIS53
F	CYS56

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 200

Chain	Residue
G	CYS21
G	CYS24
G	HIS53
G	CYS56

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 200

Chain	Residue
H	CYS21
H	CYS24
H	HIS53
H	CYS56

---

Functional Information from PROSITE/UniProt

site_id	PS00347
Number of Residues	36
Details	ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC

Chain	Residue	Details
A	CYS21-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	672
Details	ZN_FING: PARP-type 1 => ECO:0000255|PROSITE-ProRule:PRU00264

Chain	Residue	Details
A	TYR9-GLY93
B	TYR9-GLY93
C	TYR9-GLY93
D	TYR9-GLY93
E	TYR9-GLY93
F	TYR9-GLY93
G	TYR9-GLY93
H	TYR9-GLY93

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00264, ECO:0000269|PubMed:21233213, ECO:0000269|PubMed:22582261, ECO:0000269|PubMed:22683995, ECO:0007744|PDB:3OD8, ECO:0007744|PDB:3ODA, ECO:0007744|PDB:4AV1, ECO:0007744|PDB:4DQY, ECO:0007744|PDB:4OPX, ECO:0007744|PDB:4OQA, ECO:0007744|PDB:4OQB

Chain	Residue	Details
A	CYS21
C	CYS24
C	HIS53
C	CYS56
D	CYS21
D	CYS24
D	HIS53
D	CYS56
E	CYS21
E	CYS24
E	HIS53
A	CYS24
E	CYS56
F	CYS21
F	CYS24
F	HIS53
F	CYS56
G	CYS21
G	CYS24
G	HIS53
G	CYS56
H	CYS21
A	HIS53
H	CYS24
H	HIS53
H	CYS56
A	CYS56
B	CYS21
B	CYS24
B	HIS53
B	CYS56
C	CYS21

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.12, ECO:0007744|PubMed:22814378

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER41
B	SER41
C	SER41
D	SER41
E	SER41
F	SER41
G	SER41
H	SER41

---