3OD8

Human PARP-1 zinc finger 1 (Zn1) bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008270	molecular_function	zinc ion binding
B	0003677	molecular_function	DNA binding
B	0008270	molecular_function	zinc ion binding
C	0003677	molecular_function	DNA binding
C	0008270	molecular_function	zinc ion binding
D	0003677	molecular_function	DNA binding
D	0008270	molecular_function	zinc ion binding
E	0003677	molecular_function	DNA binding
E	0008270	molecular_function	zinc ion binding
F	0003677	molecular_function	DNA binding
F	0008270	molecular_function	zinc ion binding
G	0003677	molecular_function	DNA binding
G	0008270	molecular_function	zinc ion binding
H	0003677	molecular_function	DNA binding
H	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 200

Chain	Residue
A	CYS21
A	CYS24
A	HIS53
A	CYS56

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 200

Chain	Residue
B	CYS21
B	CYS24
B	HIS53
B	CYS56

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 200

Chain	Residue
C	CYS24
C	HIS53
C	CYS56
C	CYS21

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 200

Chain	Residue
D	CYS21
D	CYS24
D	HIS53
D	CYS56

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 200

Chain	Residue
E	CYS21
E	CYS24
E	HIS53
E	CYS56

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 200

Chain	Residue
F	CYS21
F	CYS24
F	HIS53
F	CYS56

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 200

Chain	Residue
G	CYS21
G	CYS24
G	HIS53
G	CYS56

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 200

Chain	Residue
H	CYS21
H	CYS24
H	HIS53
H	CYS56

---

Functional Information from PROSITE/UniProt

site_id	PS00347
Number of Residues	36
Details	ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC

Chain	Residue	Details
A	CYS21-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00264","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21233213","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22582261","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ODA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AV1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OPX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OQB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Zebisch A.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W."]}},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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