Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OCC

Crystal structure of PNP with DADMEimmH from Yersinia pseudotuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042278	biological_process	purine nucleoside metabolic process
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0042278	biological_process	purine nucleoside metabolic process
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0042278	biological_process	purine nucleoside metabolic process
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0042278	biological_process	purine nucleoside metabolic process
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0042278	biological_process	purine nucleoside metabolic process
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0042278	biological_process	purine nucleoside metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DIH A 500

Chain	Residue
A	MET65
A	SER204
A	ASP205
A	HOH455
A	PO4501
F	HIS5
F	ARG44
A	SER91
A	CYS92
A	GLY93
A	PHE160
A	VAL179
A	GLU180
A	MET181
A	GLU182

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	GLY21
A	ARG25
A	ARG88
A	GLY90
A	SER91
A	DIH500
F	ARG44

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DIH B 500

Chain	Residue
B	MET65
B	SER91
B	CYS92
B	GLY93
B	PHE160
B	VAL179
B	GLU180
B	MET181
B	GLU182
B	SER204
B	ASP205
B	HOH423
B	PO4501
C	HIS5
C	ARG44

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 501

Chain	Residue
B	GLY21
B	ARG25
B	ARG88
B	GLY90
B	SER91
B	DIH500
C	ARG44

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE DIH C 500

Chain	Residue
B	HIS5
B	ARG44
C	MET65
C	SER91
C	CYS92
C	GLY93
C	PHE160
C	VAL179
C	GLU180
C	MET181
C	GLU182
C	SER204
C	ASP205
C	ILE207
C	HOH289
C	PO4501

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 501

Chain	Residue
B	ARG44
C	GLY21
C	ARG25
C	ARG88
C	GLY90
C	SER91
C	DIH500

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DIH D 500

Chain	Residue
D	MET65
D	SER91
D	CYS92
D	GLY93
D	PHE160
D	VAL179
D	GLU180
D	MET181
D	GLU182
D	SER204
D	ASP205
D	PO4501
D	HOH1155
E	HIS5
E	ARG44

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 501

Chain	Residue
D	GLY21
D	ARG25
D	ARG88
D	GLY90
D	SER91
D	DIH500
E	ARG44

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE DIH E 500

Chain	Residue
E	GLU182
E	SER204
E	ASP205
E	HOH335
E	PO4501
E	HOH1146
D	HIS5
D	ARG44
E	MET65
E	SER91
E	CYS92
E	GLY93
E	PHE160
E	VAL179
E	GLU180
E	MET181

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E 501

Chain	Residue
D	ARG44
E	GLY21
E	ARG25
E	ARG88
E	GLY90
E	SER91
E	DIH500

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DIH F 500

Chain	Residue
A	HIS5
A	ARG44
F	MET65
F	SER91
F	CYS92
F	GLY93
F	PHE160
F	VAL179
F	GLU180
F	MET181
F	GLU182
F	SER204
F	ASP205
F	ILE207
F	PO4501

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 F 501

Chain	Residue
A	ARG44
F	GLY21
F	ARG25
F	ARG88
F	GLY90
F	SER91
F	DIH500

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIyakEL

Chain	Residue	Details
A	GLY62-LEU77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)