3OCC
Crystal structure of PNP with DADMEimmH from Yersinia pseudotuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0042278 | biological_process | purine nucleoside metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0042278 | biological_process | purine nucleoside metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0042278 | biological_process | purine nucleoside metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0042278 | biological_process | purine nucleoside metabolic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0042278 | biological_process | purine nucleoside metabolic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0042278 | biological_process | purine nucleoside metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DIH A 500 |
| Chain | Residue |
| A | MET65 |
| A | SER204 |
| A | ASP205 |
| A | HOH455 |
| A | PO4501 |
| F | HIS5 |
| F | ARG44 |
| A | SER91 |
| A | CYS92 |
| A | GLY93 |
| A | PHE160 |
| A | VAL179 |
| A | GLU180 |
| A | MET181 |
| A | GLU182 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 501 |
| Chain | Residue |
| A | GLY21 |
| A | ARG25 |
| A | ARG88 |
| A | GLY90 |
| A | SER91 |
| A | DIH500 |
| F | ARG44 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DIH B 500 |
| Chain | Residue |
| B | MET65 |
| B | SER91 |
| B | CYS92 |
| B | GLY93 |
| B | PHE160 |
| B | VAL179 |
| B | GLU180 |
| B | MET181 |
| B | GLU182 |
| B | SER204 |
| B | ASP205 |
| B | HOH423 |
| B | PO4501 |
| C | HIS5 |
| C | ARG44 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 501 |
| Chain | Residue |
| B | GLY21 |
| B | ARG25 |
| B | ARG88 |
| B | GLY90 |
| B | SER91 |
| B | DIH500 |
| C | ARG44 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DIH C 500 |
| Chain | Residue |
| B | HIS5 |
| B | ARG44 |
| C | MET65 |
| C | SER91 |
| C | CYS92 |
| C | GLY93 |
| C | PHE160 |
| C | VAL179 |
| C | GLU180 |
| C | MET181 |
| C | GLU182 |
| C | SER204 |
| C | ASP205 |
| C | ILE207 |
| C | HOH289 |
| C | PO4501 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 501 |
| Chain | Residue |
| B | ARG44 |
| C | GLY21 |
| C | ARG25 |
| C | ARG88 |
| C | GLY90 |
| C | SER91 |
| C | DIH500 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DIH D 500 |
| Chain | Residue |
| D | MET65 |
| D | SER91 |
| D | CYS92 |
| D | GLY93 |
| D | PHE160 |
| D | VAL179 |
| D | GLU180 |
| D | MET181 |
| D | GLU182 |
| D | SER204 |
| D | ASP205 |
| D | PO4501 |
| D | HOH1155 |
| E | HIS5 |
| E | ARG44 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 501 |
| Chain | Residue |
| D | GLY21 |
| D | ARG25 |
| D | ARG88 |
| D | GLY90 |
| D | SER91 |
| D | DIH500 |
| E | ARG44 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DIH E 500 |
| Chain | Residue |
| E | GLU182 |
| E | SER204 |
| E | ASP205 |
| E | HOH335 |
| E | PO4501 |
| E | HOH1146 |
| D | HIS5 |
| D | ARG44 |
| E | MET65 |
| E | SER91 |
| E | CYS92 |
| E | GLY93 |
| E | PHE160 |
| E | VAL179 |
| E | GLU180 |
| E | MET181 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 501 |
| Chain | Residue |
| D | ARG44 |
| E | GLY21 |
| E | ARG25 |
| E | ARG88 |
| E | GLY90 |
| E | SER91 |
| E | DIH500 |
| site_id | BC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE DIH F 500 |
| Chain | Residue |
| A | HIS5 |
| A | ARG44 |
| F | MET65 |
| F | SER91 |
| F | CYS92 |
| F | GLY93 |
| F | PHE160 |
| F | VAL179 |
| F | GLU180 |
| F | MET181 |
| F | GLU182 |
| F | SER204 |
| F | ASP205 |
| F | ILE207 |
| F | PO4501 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 F 501 |
| Chain | Residue |
| A | ARG44 |
| F | GLY21 |
| F | ARG25 |
| F | ARG88 |
| F | GLY90 |
| F | SER91 |
| F | DIH500 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiPScSIyakEL |
| Chain | Residue | Details |
| A | GLY62-LEU77 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627 |
| Chain | Residue | Details |
| A | ASP205 | |
| B | ASP205 | |
| C | ASP205 | |
| D | ASP205 | |
| E | ASP205 | |
| F | ASP205 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P50389 |
| Chain | Residue | Details |
| A | HIS5 | |
| E | ARG44 | |
| F | HIS5 | |
| F | ARG44 | |
| A | ARG44 | |
| B | HIS5 | |
| B | ARG44 | |
| C | HIS5 | |
| C | ARG44 | |
| D | HIS5 | |
| D | ARG44 | |
| E | HIS5 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:P50389 |
| Chain | Residue | Details |
| A | GLY21 | |
| B | SER204 | |
| C | GLY21 | |
| C | ARG25 | |
| C | ARG88 | |
| C | GLU180 | |
| C | SER204 | |
| D | GLY21 | |
| D | ARG25 | |
| D | ARG88 | |
| D | GLU180 | |
| A | ARG25 | |
| D | SER204 | |
| E | GLY21 | |
| E | ARG25 | |
| E | ARG88 | |
| E | GLU180 | |
| E | SER204 | |
| F | GLY21 | |
| F | ARG25 | |
| F | ARG88 | |
| F | GLU180 | |
| A | ARG88 | |
| F | SER204 | |
| A | GLU180 | |
| A | SER204 | |
| B | GLY21 | |
| B | ARG25 | |
| B | ARG88 | |
| B | GLU180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627 |
| Chain | Residue | Details |
| A | ARG218 | |
| B | ARG218 | |
| C | ARG218 | |
| D | ARG218 | |
| E | ARG218 | |
| F | ARG218 |
