3OBA
Structure of the beta-galactosidase from Kluyveromyces lactis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004565 | molecular_function | beta-galactosidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0005990 | biological_process | lactose catabolic process |
| A | 0009341 | cellular_component | beta-galactosidase complex |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030246 | molecular_function | carbohydrate binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004565 | molecular_function | beta-galactosidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0005990 | biological_process | lactose catabolic process |
| B | 0009341 | cellular_component | beta-galactosidase complex |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030246 | molecular_function | carbohydrate binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0004565 | molecular_function | beta-galactosidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0005990 | biological_process | lactose catabolic process |
| C | 0009341 | cellular_component | beta-galactosidase complex |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0030246 | molecular_function | carbohydrate binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0004565 | molecular_function | beta-galactosidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0005990 | biological_process | lactose catabolic process |
| D | 0009341 | cellular_component | beta-galactosidase complex |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0030246 | molecular_function | carbohydrate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 A 2001 |
| Chain | Residue |
| A | ASP593 |
| A | HIS975 |
| A | ASP978 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1026 |
| Chain | Residue |
| A | PHE218 |
| A | ASP220 |
| A | TYR223 |
| A | GLN332 |
| A | GLU334 |
| A | LYS336 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1027 |
| Chain | Residue |
| A | TRP789 |
| A | ARG790 |
| A | PRO791 |
| A | GLU883 |
| A | ARG988 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 C 2001 |
| Chain | Residue |
| C | ASP593 |
| C | HIS975 |
| C | ASP978 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 1026 |
| Chain | Residue |
| C | GLN188 |
| C | TRP189 |
| C | HIS355 |
| C | ASP356 |
| C | HIS357 |
| C | GLY362 |
| C | ARG363 |
| C | TYR390 |
| C | HIS587 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1027 |
| Chain | Residue |
| A | LEU764 |
| A | GLY783 |
| A | LYS813 |
| A | GLN814 |
| A | ASN815 |
| C | PRO101 |
| C | VAL103 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL C 1028 |
| Chain | Residue |
| C | SER562 |
| C | LEU563 |
| C | LYS564 |
| C | GLU638 |
| C | VAL642 |
| C | ASP906 |
| C | LYS907 |
| C | LYS908 |
| C | GLU909 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1029 |
| Chain | Residue |
| A | PRO101 |
| A | VAL103 |
| C | LEU764 |
| C | GLY783 |
| C | GLN814 |
| C | ASN815 |
| C | HOH1329 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 D 2001 |
| Chain | Residue |
| D | ASP593 |
| D | HIS975 |
| D | ASP978 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 1026 |
| Chain | Residue |
| D | ASN627 |
| D | ASN631 |
| D | HOH1282 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 1027 |
| Chain | Residue |
| B | PRO101 |
| B | VAL103 |
| D | LEU764 |
| D | PHE781 |
| D | GLY783 |
| D | LYS813 |
| D | GLN814 |
| D | ASN815 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 B 2001 |
| Chain | Residue |
| B | ASP593 |
| B | HIS975 |
| B | ASP978 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1026 |
| Chain | Residue |
| B | LYS780 |
| B | TRP789 |
| B | ARG790 |
| B | GLU883 |
| B | ARG988 |
| B | HOH1315 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1027 |
| Chain | Residue |
| B | PHE781 |
| B | GLY783 |
| B | LYS813 |
| B | GLN814 |
| B | ASN815 |
| D | THR102 |
| D | VAL103 |
Functional Information from PROSITE/UniProt
| site_id | PS00608 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DVNHPSIIIWSlg.NE |
| Chain | Residue | Details |
| A | ASP468-GLU482 |
| site_id | PS00719 |
| Number of Residues | 26 |
| Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRNSHYPnhpkVYdlfDklGFWVI |
| Chain | Residue | Details |
| A | ASN383-ILE408 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU482 | |
| C | GLU482 | |
| D | GLU482 | |
| B | GLU482 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU551 | |
| C | GLU551 | |
| D | GLU551 | |
| B | GLU551 |
