3O9M
Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001540 | molecular_function | amyloid-beta binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003990 | molecular_function | acetylcholinesterase activity |
A | 0004104 | molecular_function | cholinesterase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005641 | cellular_component | nuclear envelope lumen |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005788 | cellular_component | endoplasmic reticulum lumen |
A | 0005886 | cellular_component | plasma membrane |
A | 0006581 | biological_process | acetylcholine catabolic process |
A | 0006805 | biological_process | xenobiotic metabolic process |
A | 0007584 | biological_process | response to nutrient |
A | 0007612 | biological_process | learning |
A | 0008285 | biological_process | negative regulation of cell population proliferation |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0014016 | biological_process | neuroblast differentiation |
A | 0016486 | biological_process | peptide hormone processing |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
A | 0019695 | biological_process | choline metabolic process |
A | 0019899 | molecular_function | enzyme binding |
A | 0033265 | molecular_function | choline binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0043279 | biological_process | response to alkaloid |
A | 0050783 | biological_process | cocaine metabolic process |
A | 0050805 | biological_process | negative regulation of synaptic transmission |
A | 0051384 | biological_process | response to glucocorticoid |
A | 0051593 | biological_process | response to folic acid |
A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
A | 0072562 | cellular_component | blood microparticle |
B | 0001540 | molecular_function | amyloid-beta binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003990 | molecular_function | acetylcholinesterase activity |
B | 0004104 | molecular_function | cholinesterase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005641 | cellular_component | nuclear envelope lumen |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005788 | cellular_component | endoplasmic reticulum lumen |
B | 0005886 | cellular_component | plasma membrane |
B | 0006581 | biological_process | acetylcholine catabolic process |
B | 0006805 | biological_process | xenobiotic metabolic process |
B | 0007584 | biological_process | response to nutrient |
B | 0007612 | biological_process | learning |
B | 0008285 | biological_process | negative regulation of cell population proliferation |
B | 0009410 | biological_process | response to xenobiotic stimulus |
B | 0014016 | biological_process | neuroblast differentiation |
B | 0016486 | biological_process | peptide hormone processing |
B | 0016787 | molecular_function | hydrolase activity |
B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
B | 0019695 | biological_process | choline metabolic process |
B | 0019899 | molecular_function | enzyme binding |
B | 0033265 | molecular_function | choline binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0043279 | biological_process | response to alkaloid |
B | 0050783 | biological_process | cocaine metabolic process |
B | 0050805 | biological_process | negative regulation of synaptic transmission |
B | 0051384 | biological_process | response to glucocorticoid |
B | 0051593 | biological_process | response to folic acid |
B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
B | 0072562 | cellular_component | blood microparticle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BEZ A 999 |
Chain | Residue |
A | GLY116 |
A | GLY117 |
A | SER198 |
A | LEU286 |
A | HIS438 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE BEZ B 999 |
Chain | Residue |
B | GLY116 |
B | GLY117 |
B | SER198 |
B | HIS438 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10039","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PDB","id":"4BDS","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Binding site: {} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22444575","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3542989","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |