3O80

Crystal structure of monomeric KlHxk1 in crystal form IX (open state)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ANP A 486

Chain	Residue
A	SER347
A	LYS348
A	ASP351
A	ARG422

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ANP A 487

Chain	Residue
A	GLU39
A	LEU386
A	THR389
A	ARG390
A	ARG393
A	ASP436
A	PHE34
A	THR35
A	VAL36
A	SER37
A	SER38

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Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqkkINsgvLqrWTKgF

Chain	Residue	Details
A	LEU152-PHE177

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS111

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:12882981

Chain	Residue	Details
A	SER15

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