Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3O7M

1.98 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor'

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 184

Chain	Residue
A	ILE101
A	ASP102
A	SER103
A	GLY104
A	LEU105
A	THR106
A	LEU107
A	HOH413
A	HOH510

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 184

Chain	Residue
C	GLU98
C	ILE100
C	ILE101
C	ASP102
C	SER103
C	GLY104
C	LEU105
C	THR106
C	LEU107
C	HOH487

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 185

Chain	Residue
A	LEU41
A	LYS42
A	GLY43
A	ARG164
A	HOH275

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 186

Chain	Residue
A	HIS54
A	LYS56
A	HOH368
D	ARG28
D	HOH273

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 184

Chain	Residue
B	LEU41
B	LYS42
B	GLY43
B	ASP158
B	ARG164
B	HOH351
B	HOH439
B	HOH502

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 185

Chain	Residue
B	ASP102
B	SER103
B	GLY104
B	LEU105
B	THR106
B	LEU107
B	HOH528

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 185

Chain	Residue
C	LEU41
C	LYS42
C	GLY43
C	ASP158
C	ARG164
C	HOH364
C	HOH477

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 184

Chain	Residue
D	LEU41
D	LYS42
D	GLY43
D	ARG164
D	HOH215
D	HOH336

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 185

Chain	Residue
A	ARG28
D	HIS54
D	LYS56
D	HOH235
D	HOH482

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 186

Chain	Residue
D	GLU98
D	ASP102
D	SER103
D	GLY104
D	LEU105
D	THR106
D	LEU107
D	HOH362
D	HOH382

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 187

Chain	Residue
D	ASP102
D	LYS130
D	ARG133
D	PHE151
D	HOH219
D	HOH220
D	HOH402

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 187

Chain	Residue
A	ILE3
A	PHE151
A	CYS159
A	HOH398

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME B 186

Chain	Residue
B	PHE151
B	CYS159

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME C 186

Chain	Residue
C	PHE151
C	CYS159

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME D 188

Chain	Residue
D	PHE151
D	CYS159

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VIVVEDIIDSGlT

Chain	Residue	Details
A	VAL94-THR106

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)