3O7M
1.98 Angstrom resolution crystal structure of a hypoxanthine-guanine phosphoribosyltransferase (hpt-2) from Bacillus anthracis str. 'Ames Ancestor'
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006178 | biological_process | guanine salvage |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006178 | biological_process | guanine salvage |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006178 | biological_process | guanine salvage |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006178 | biological_process | guanine salvage |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 184 |
| Chain | Residue |
| A | ILE101 |
| A | ASP102 |
| A | SER103 |
| A | GLY104 |
| A | LEU105 |
| A | THR106 |
| A | LEU107 |
| A | HOH413 |
| A | HOH510 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C 184 |
| Chain | Residue |
| C | GLU98 |
| C | ILE100 |
| C | ILE101 |
| C | ASP102 |
| C | SER103 |
| C | GLY104 |
| C | LEU105 |
| C | THR106 |
| C | LEU107 |
| C | HOH487 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 185 |
| Chain | Residue |
| A | LEU41 |
| A | LYS42 |
| A | GLY43 |
| A | ARG164 |
| A | HOH275 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 186 |
| Chain | Residue |
| A | HIS54 |
| A | LYS56 |
| A | HOH368 |
| D | ARG28 |
| D | HOH273 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 184 |
| Chain | Residue |
| B | LEU41 |
| B | LYS42 |
| B | GLY43 |
| B | ASP158 |
| B | ARG164 |
| B | HOH351 |
| B | HOH439 |
| B | HOH502 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 185 |
| Chain | Residue |
| B | ASP102 |
| B | SER103 |
| B | GLY104 |
| B | LEU105 |
| B | THR106 |
| B | LEU107 |
| B | HOH528 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 185 |
| Chain | Residue |
| C | LEU41 |
| C | LYS42 |
| C | GLY43 |
| C | ASP158 |
| C | ARG164 |
| C | HOH364 |
| C | HOH477 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 184 |
| Chain | Residue |
| D | LEU41 |
| D | LYS42 |
| D | GLY43 |
| D | ARG164 |
| D | HOH215 |
| D | HOH336 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 185 |
| Chain | Residue |
| A | ARG28 |
| D | HIS54 |
| D | LYS56 |
| D | HOH235 |
| D | HOH482 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 186 |
| Chain | Residue |
| D | GLU98 |
| D | ASP102 |
| D | SER103 |
| D | GLY104 |
| D | LEU105 |
| D | THR106 |
| D | LEU107 |
| D | HOH362 |
| D | HOH382 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 187 |
| Chain | Residue |
| D | ASP102 |
| D | LYS130 |
| D | ARG133 |
| D | PHE151 |
| D | HOH219 |
| D | HOH220 |
| D | HOH402 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 187 |
| Chain | Residue |
| A | ILE3 |
| A | PHE151 |
| A | CYS159 |
| A | HOH398 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME B 186 |
| Chain | Residue |
| B | PHE151 |
| B | CYS159 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME C 186 |
| Chain | Residue |
| C | PHE151 |
| C | CYS159 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME D 188 |
| Chain | Residue |
| D | PHE151 |
| D | CYS159 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VIVVEDIIDSGlT |
| Chain | Residue | Details |
| A | VAL94-THR106 |
