3O4W
Crystal structure of dimeric KlHxk1 in crystal form IV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006013 | biological_process | mannose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| A | 0019158 | molecular_function | mannokinase activity |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0046323 | biological_process | D-glucose import |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 1990539 | biological_process | fructose import across plasma membrane |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004340 | molecular_function | glucokinase activity |
| B | 0004396 | molecular_function | hexokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005536 | molecular_function | D-glucose binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006013 | biological_process | mannose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008865 | molecular_function | fructokinase activity |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| B | 0019158 | molecular_function | mannokinase activity |
| B | 0019318 | biological_process | hexose metabolic process |
| B | 0046323 | biological_process | D-glucose import |
| B | 0046835 | biological_process | carbohydrate phosphorylation |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 1990539 | biological_process | fructose import across plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NHE A 486 |
| Chain | Residue |
| A | TYR112 |
| A | GLU136 |
| A | HOH782 |
| B | ASN356 |
| B | VAL374 |
| B | ARG377 |
| B | SO4496 |
| B | HOH732 |
| B | HOH889 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NHE A 487 |
| Chain | Residue |
| A | HIS117 |
| A | GLN125 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 488 |
| Chain | Residue |
| A | ASN209 |
| A | ASP210 |
| A | THR211 |
| A | ILE230 |
| A | GLY234 |
| A | VAL235 |
| A | ASN236 |
| B | VAL2 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 489 |
| Chain | Residue |
| A | THR90 |
| A | ASN91 |
| A | LYS111 |
| A | ARG113 |
| A | HOH742 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 490 |
| Chain | Residue |
| A | GLY232 |
| A | THR233 |
| A | GLY417 |
| A | SER418 |
| A | HOH635 |
| A | HOH749 |
| B | VAL2 |
| B | ARG3 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 491 |
| Chain | Residue |
| A | GLU180 |
| A | GLY181 |
| A | HOH541 |
| A | HOH557 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 492 |
| Chain | Residue |
| A | SER292 |
| A | ARG294 |
| A | GLN298 |
| A | LYS302 |
| A | TYR308 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 493 |
| Chain | Residue |
| A | GLN432 |
| A | LYS435 |
| A | HOH516 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 494 |
| Chain | Residue |
| A | LYS444 |
| A | MET445 |
| A | HOH593 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 495 |
| Chain | Residue |
| A | SER15 |
| A | MET16 |
| A | ALA17 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 496 |
| Chain | Residue |
| A | PRO20 |
| A | ALA21 |
| A | HOH804 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 497 |
| Chain | Residue |
| A | GLY417 |
| A | SER418 |
| A | ASN421 |
| A | ARG422 |
| B | ARG3 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 498 |
| Chain | Residue |
| A | GLU39 |
| A | ARG42 |
| A | LYS46 |
| A | HOH663 |
| site_id | BC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NHE B 486 |
| Chain | Residue |
| A | LYS40 |
| A | HIS276 |
| A | LEU277 |
| A | VAL278 |
| A | LEU279 |
| A | HOH890 |
| B | THR32 |
| B | LEU33 |
| B | LYS40 |
| B | HOH533 |
| B | HOH569 |
| B | HOH893 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NHE B 487 |
| Chain | Residue |
| A | ASN356 |
| A | VAL374 |
| A | ARG377 |
| B | TYR112 |
| B | CYS133 |
| B | GLU136 |
| B | HOH631 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 488 |
| Chain | Residue |
| A | VAL2 |
| B | ASN209 |
| B | ASP210 |
| B | THR211 |
| B | GLY234 |
| B | ASN236 |
| B | HOH683 |
| B | HOH775 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 489 |
| Chain | Residue |
| A | VAL2 |
| B | GLY232 |
| B | THR233 |
| B | GLY417 |
| B | SER418 |
| B | HOH794 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 490 |
| Chain | Residue |
| B | GLN432 |
| B | LYS435 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 491 |
| Chain | Residue |
| B | GLN298 |
| B | LYS302 |
| B | TYR308 |
| B | SER292 |
| B | ARG294 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 492 |
| Chain | Residue |
| B | PHE420 |
| B | LYS427 |
| B | VAL453 |
| B | ALA454 |
| B | HOH518 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 493 |
| Chain | Residue |
| B | THR90 |
| B | ASN91 |
| B | LYS111 |
| B | ARG113 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 494 |
| Chain | Residue |
| A | LYS283 |
| B | HIS276 |
| B | ARG281 |
| B | VAL286 |
| B | HOH564 |
| B | HOH680 |
| B | HOH793 |
| B | HOH873 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 495 |
| Chain | Residue |
| B | PRO20 |
| B | ALA21 |
| B | HOH531 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 496 |
| Chain | Residue |
| A | NHE486 |
| A | HOH790 |
| B | THR373 |
| B | VAL374 |
| B | HOH559 |
| B | HOH732 |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqkkINsgvLqrWTKgF |
| Chain | Residue | Details |
| A | LEU152-PHE177 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 894 |
| Details | Domain: {"description":"Hexokinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 266 |
| Details | Region: {"description":"Hexokinase small subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Region: {"description":"Glucose-binding","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 496 |
| Details | Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12882981","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
