3O0O
Thermotoga maritima Ribonucleotide Reductase, NrdJ, in complex with dTTP, GDP and Adenosylcobalamin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0031419 | molecular_function | cobalamin binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0031419 | molecular_function | cobalamin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE TTP A 1001 |
| Chain | Residue |
| A | ASP141 |
| A | SER185 |
| A | PHE190 |
| A | HOH649 |
| A | HOH651 |
| A | HOH676 |
| A | HOH680 |
| A | HOH700 |
| A | HOH750 |
| A | HOH755 |
| A | MG1002 |
| A | SER142 |
| B | LYS158 |
| B | VAL200 |
| B | VAL201 |
| B | LYS202 |
| A | ILE143 |
| A | ILE146 |
| A | ARG171 |
| A | VAL177 |
| A | ALA178 |
| A | GLY179 |
| A | ALA184 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH649 |
| A | HOH679 |
| A | HOH749 |
| A | TTP1001 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDP A 1003 |
| Chain | Residue |
| A | ASN90 |
| A | SER91 |
| A | PRO92 |
| A | PHE95 |
| A | ALA133 |
| A | CYS134 |
| A | GLY161 |
| A | GLY162 |
| A | ARG207 |
| A | ARG208 |
| A | ASN320 |
| A | PRO321 |
| A | CYS322 |
| A | GLU324 |
| A | ALA489 |
| A | PRO490 |
| A | THR491 |
| A | GLY492 |
| A | SER493 |
| A | ILE494 |
| A | HOH703 |
| A | HOH719 |
| A | B121004 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE B12 A 1004 |
| Chain | Residue |
| A | ARG208 |
| A | GLY294 |
| A | CYS322 |
| A | GLY492 |
| A | ASN496 |
| A | PHE508 |
| A | THR598 |
| A | ASN600 |
| A | THR626 |
| A | TYR628 |
| A | ASP630 |
| A | HOH693 |
| A | HOH726 |
| A | HOH780 |
| A | HOH782 |
| A | GDP1003 |
| A | 5AD1005 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 5AD A 1005 |
| Chain | Residue |
| A | ASN242 |
| A | LEU243 |
| A | SER244 |
| A | ASP295 |
| A | CYS322 |
| A | SER596 |
| A | THR598 |
| A | THR626 |
| A | HOH707 |
| A | HOH785 |
| A | B121004 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE TTP B 1001 |
| Chain | Residue |
| A | LYS158 |
| A | VAL200 |
| A | LYS202 |
| B | ASP141 |
| B | SER142 |
| B | ILE143 |
| B | ARG171 |
| B | VAL177 |
| B | ALA178 |
| B | GLY179 |
| B | ALA184 |
| B | SER185 |
| B | PHE190 |
| B | HOH700 |
| B | HOH801 |
| B | MG1002 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | SER142 |
| B | HOH801 |
| B | TTP1001 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GDP B 1003 |
| Chain | Residue |
| B | PHE95 |
| B | ALA133 |
| B | CYS134 |
| B | GLY161 |
| B | ARG206 |
| B | ARG208 |
| B | ALA210 |
| B | ASN320 |
| B | PRO321 |
| B | CYS322 |
| B | GLU324 |
| B | ALA489 |
| B | PRO490 |
| B | THR491 |
| B | GLY492 |
| B | SER493 |
| B | ILE494 |
| B | HOH645 |
| B | HOH689 |
| B | HOH785 |
| B | HOH947 |
| B | HOH948 |
| B | B121004 |
| B | ASN90 |
| B | SER91 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE B12 B 1004 |
| Chain | Residue |
| B | ARG26 |
| B | ARG206 |
| B | ARG208 |
| B | ASN242 |
| B | GLY294 |
| B | ASP295 |
| B | CYS322 |
| B | GLY492 |
| B | ASN496 |
| B | PHE508 |
| B | ASN600 |
| B | TYR628 |
| B | HOH705 |
| B | HOH714 |
| B | HOH726 |
| B | HOH736 |
| B | HOH812 |
| B | HOH879 |
| B | HOH947 |
| B | HOH950 |
| B | HOH955 |
| B | GDP1003 |
| B | 5AD1005 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 5AD B 1005 |
| Chain | Residue |
| B | MET212 |
| B | ASN242 |
| B | LEU243 |
| B | SER244 |
| B | CYS322 |
| B | GLY323 |
| B | SER596 |
| B | THR626 |
| B | HOH682 |
| B | HOH758 |
| B | HOH798 |
| B | HOH880 |
| B | B121004 |
