3O0H
Crystal structure of glutathione reductase from Bartonella henselae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 501 |
| Chain | Residue |
| A | VAL18 |
| A | ARG19 |
| A | ARG22 |
| A | HOH615 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 502 |
| Chain | Residue |
| A | ASP210 |
| A | TYR211 |
| A | SER356 |
| A | GLU357 |
| A | GLU358 |
| site_id | AC3 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | ILE11 |
| A | GLY12 |
| A | GLY14 |
| A | SER15 |
| A | GLY16 |
| A | ALA34 |
| A | GLU35 |
| A | GLU36 |
| A | GLY41 |
| A | THR42 |
| A | CYS43 |
| A | GLY47 |
| A | CYS48 |
| A | LYS51 |
| A | SER113 |
| A | ARG114 |
| A | ALA115 |
| A | ALA140 |
| A | THR141 |
| A | GLY142 |
| A | SER160 |
| A | TYR180 |
| A | ARG265 |
| A | GLY304 |
| A | ASP305 |
| A | GLN311 |
| A | LEU312 |
| A | THR313 |
| A | PRO314 |
| A | ALA316 |
| A | HOH470 |
| A | HOH475 |
| A | HOH490 |
| A | HOH526 |
| A | HOH535 |
| A | HOH628 |
| A | HOH683 |
| A | HOH718 |
| B | HIS438 |
| B | PRO439 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 501 |
| Chain | Residue |
| B | ARG19 |
| B | ARG22 |
| B | HOH577 |
| B | HOH640 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 502 |
| Chain | Residue |
| B | ASP210 |
| B | TYR211 |
| B | GLU358 |
| B | HOH803 |
| site_id | AC6 |
| Number of Residues | 43 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| B | HOH569 |
| A | HIS438 |
| A | PRO439 |
| A | HOH543 |
| B | ILE11 |
| B | GLY12 |
| B | GLY14 |
| B | SER15 |
| B | GLY16 |
| B | ALA34 |
| B | GLU35 |
| B | GLU36 |
| B | GLY41 |
| B | THR42 |
| B | CYS43 |
| B | GLY47 |
| B | CYS48 |
| B | LYS51 |
| B | SER113 |
| B | ARG114 |
| B | ALA115 |
| B | ALA140 |
| B | THR141 |
| B | GLY142 |
| B | SER160 |
| B | TYR180 |
| B | ARG265 |
| B | ASN268 |
| B | LEU272 |
| B | GLY304 |
| B | ASP305 |
| B | GLN311 |
| B | LEU312 |
| B | THR313 |
| B | PRO314 |
| B | ALA316 |
| B | HOH467 |
| B | HOH476 |
| B | HOH479 |
| B | HOH483 |
| B | HOH486 |
| B | HOH499 |
| B | HOH562 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVirGCVP |
| Chain | Residue | Details |
| A | GLY40-PRO50 |
