3NZT

2.0 Angstrom Crystal structure of Glutamate--Cysteine Ligase (gshA) ftom Francisella tularensis in Complex with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004357	molecular_function	glutamate-cysteine ligase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006750	biological_process	glutathione biosynthetic process
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AMP A 502

Chain	Residue
A	LEU10
A	ILE289
A	GLU306
A	TYR307
A	HOH741
A	HOH782
A	HOH795
A	HOH805
A	HOH831
A	GLY12
A	ILE13
A	ILE56
A	THR57
A	LYS58
A	PRO59
A	ASN139
A	SER141

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	SER62
A	ILE63
A	ASP64
A	LYS325
A	GLU404
A	HOH636
A	HOH833
A	HOH835

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	THR250
A	LYS255
A	SER379
A	GLU380
A	HOH669

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	LYS115
A	ARG119
A	HOH702
A	HOH785

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
A	HIS137
A	ASN278
A	ARG285
A	ARG311
A	HOH532
A	HOH655
A	HOH725
A	HOH792
A	HOH809

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	GLU16
A	ILE133
A	SER134
A	GLY135
A	HIS137
A	ARG215
A	HOH541
A	HOH576
A	HOH810

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 508

Chain	Residue
A	ASN278
A	LYS287
A	PRO296
A	HOH613
A	HOH690
A	HOH798

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 509

Chain	Residue
A	THR21
A	CYS23
A	ASN25

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 510

Chain	Residue
A	HIS60
A	ASP61
A	LYS65

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 511

Chain	Residue
A	HIS82
A	SER83

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 512

Chain	Residue
A	ARG113
A	GLN265
A	ARG266
A	HOH580
A	HOH819

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 513

Chain	Residue
A	PRO402
A	LYS403
A	HOH730

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