Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3NZ2

Crystal Structure of Hexapeptide-Repeat containing-Acetyltransferase VCA0836 Complexed with Acetyl Co Enzyme A from Vibrio cholerae O1 biovar eltor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0008374	molecular_function	O-acyltransferase activity
A	0016407	molecular_function	acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046872	molecular_function	metal ion binding
B	0005829	cellular_component	cytosol
B	0008374	molecular_function	O-acyltransferase activity
B	0016407	molecular_function	acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046872	molecular_function	metal ion binding
C	0005829	cellular_component	cytosol
C	0008374	molecular_function	O-acyltransferase activity
C	0016407	molecular_function	acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046872	molecular_function	metal ion binding
D	0005829	cellular_component	cytosol
D	0008374	molecular_function	O-acyltransferase activity
D	0016407	molecular_function	acetyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046872	molecular_function	metal ion binding
E	0005829	cellular_component	cytosol
E	0008374	molecular_function	O-acyltransferase activity
E	0016407	molecular_function	acetyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046872	molecular_function	metal ion binding
F	0005829	cellular_component	cytosol
F	0008374	molecular_function	O-acyltransferase activity
F	0016407	molecular_function	acetyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046872	molecular_function	metal ion binding
G	0005829	cellular_component	cytosol
G	0008374	molecular_function	O-acyltransferase activity
G	0016407	molecular_function	acetyltransferase activity
G	0016740	molecular_function	transferase activity
G	0016746	molecular_function	acyltransferase activity
G	0046872	molecular_function	metal ion binding
H	0005829	cellular_component	cytosol
H	0008374	molecular_function	O-acyltransferase activity
H	0016407	molecular_function	acetyltransferase activity
H	0016740	molecular_function	transferase activity
H	0016746	molecular_function	acyltransferase activity
H	0046872	molecular_function	metal ion binding
I	0005829	cellular_component	cytosol
I	0008374	molecular_function	O-acyltransferase activity
I	0016407	molecular_function	acetyltransferase activity
I	0016740	molecular_function	transferase activity
I	0016746	molecular_function	acyltransferase activity
I	0046872	molecular_function	metal ion binding
J	0005829	cellular_component	cytosol
J	0008374	molecular_function	O-acyltransferase activity
J	0016407	molecular_function	acetyltransferase activity
J	0016740	molecular_function	transferase activity
J	0016746	molecular_function	acyltransferase activity
J	0046872	molecular_function	metal ion binding
K	0005829	cellular_component	cytosol
K	0008374	molecular_function	O-acyltransferase activity
K	0016407	molecular_function	acetyltransferase activity
K	0016740	molecular_function	transferase activity
K	0016746	molecular_function	acyltransferase activity
K	0046872	molecular_function	metal ion binding
L	0005829	cellular_component	cytosol
L	0008374	molecular_function	O-acyltransferase activity
L	0016407	molecular_function	acetyltransferase activity
L	0016740	molecular_function	transferase activity
L	0016746	molecular_function	acyltransferase activity
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACO A 195

Chain	Residue
A	TYR109
A	HOH732
A	HOH993
C	PHE81
C	ASN83
C	TRP137
C	GLY139
C	GLY140
C	ALA157
C	ALA158
C	LEU171
A	HIS113
C	GLY173
C	GLY174
C	LEU180
C	ARG181
A	ASN145
A	ASN163
A	THR175
A	PRO176
A	HOH204
A	HOH460
A	HOH463

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 196

Chain	Residue
A	LEU40
A	GLU42
A	ARG45
B	SER27

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 197

Chain	Residue
A	PHE15
A	GLY17
A	TRP123
A	HOH198

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ACO A 193

Chain	Residue
A	ASN83
A	LEU101
A	ILE102
A	GLY103
A	TRP137
A	GLY139
A	GLY140
A	ALA157
A	ALA158
A	LEU171
A	GLY174
A	LEU180
A	HOH217
B	TYR109
B	HIS113
B	ASN145
B	ASN163
B	THR175
B	PRO176

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 196

Chain	Residue
B	HIS113
B	THR125

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 197

Chain	Residue
B	GLY17

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY B 198

Chain	Residue
B	ASP98
B	HIS99
B	ASP135
E	ARG153

site_id	AC8
Number of Residues	24
Details	BINDING SITE FOR RESIDUE ACO C 195

Chain	Residue
B	ASN83
B	GLY103
B	PRO104
B	TRP137
B	GLY139
B	GLY140
B	ALA158
B	GLY174
B	LEU180
B	ARG181
B	HOH194
B	HOH818
B	HOH970
C	LEU89
C	TYR109
C	ALA111
C	HIS113
C	LEU115
C	ASN163
C	THR175
C	PRO176
C	HOH202
C	HOH641
C	HOH969

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 196

Chain	Residue
C	ALA177

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 197

Chain	Residue
B	ASN159
B	HOH268
C	ASN159
C	THR175
C	HOH199

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ACO D 195

Chain	Residue
D	HOH601
E	ALA111
E	HIS113
E	ASN145
E	VAL161
E	ASN163
E	THR175
D	ASN83
D	GLY103
D	PRO104
D	TRP137
D	GLY139
D	GLY140
D	ALA157
D	ALA158
D	GLY174
D	LEU180
D	HOH196
D	HOH200

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY D 197

Chain	Residue
D	LYS59
D	HIS79
E	GLN121
E	TRP123

site_id	BC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE ACO E 195

Chain	Residue
E	ASN83
E	GLY103
E	PRO104
E	TRP137
E	GLY139
E	GLY140
E	ALA157
E	ALA158
E	GLY174
E	LEU180
E	ARG181
E	HOH202
E	HOH203
E	HOH207
E	HOH688
F	LEU89
F	TYR109
F	HIS113
F	ASN163
F	THR175

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 196

Chain	Residue
E	GLU42
E	ARG45
E	GLN49
E	VAL62
E	GLN63
E	PRO64

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 193

Chain	Residue
E	HIS79

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY F 196

Chain	Residue
D	GLN121
D	ALA122
D	TRP123
F	HIS79

site_id	BC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACO F 195

Chain	Residue
D	LEU89
D	TYR109
D	HIS113
D	LEU115
D	ASN163
D	THR175
D	PRO176
F	ASN83
F	PRO104
F	TRP137
F	GLY139
F	GLY140
F	ALA157
F	ALA158
F	LEU171
F	GLY174
F	ARG181
F	HOH204
F	HOH530
F	HOH646
F	HOH916

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL F 197

Chain	Residue
F	GLU42
F	ARG45
F	GLN49
F	CYS61
F	VAL62
F	GLN63

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY G 196

Chain	Residue
G	GLU42
G	ARG45
G	GLN49
G	CYS61
G	VAL62
G	GLN63

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BU1 G 197

Chain	Residue
G	HIS14
G	PHE15
G	TRP123
G	GLU124
G	THR125

site_id	CC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ACO H 195

Chain	Residue
G	TYR109
G	HIS113
G	ASN145
G	ASN163
G	THR175
G	HOH695
H	PHE81
H	ASN83
H	LEU101
H	ILE102
H	TRP137
H	GLY139
H	GLY140
H	ALA157
H	ALA158
H	GLY173
H	GLY174
H	LEU180
H	ARG181
H	HOH193
H	HOH354
H	HOH506
H	HOH975

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 196

Chain	Residue
H	HIS14
H	SER114
H	ILE126

site_id	CC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ACO I 195

Chain	Residue
G	ASN83
G	GLY103
G	PRO104
G	GLY139
G	GLY140
G	ALA157
G	ALA158
G	GLY174
G	ARG181
G	HOH199
G	HOH777
I	LEU89
I	TYR109
I	HIS113
I	ASN145
I	ASN163
I	THR175
I	HOH210
L	LYS11

site_id	CC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACO I 193

Chain	Residue
H	LEU89
H	ALA111
H	HIS113
H	LEU115
H	VAL161
H	ASN163
H	THR175
I	PHE81
I	ASN83
I	GLY103
I	TRP137
I	GLY139
I	GLY140
I	ALA157
I	ALA158
I	GLY174
I	ARG181
I	HOH199
I	HOH691
I	HOH864
I	HOH973

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY I 196

Chain	Residue
I	LYS59
I	HIS79

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL J 196

Chain	Residue
J	ASN37

site_id	CC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ACO J 195

Chain	Residue
J	ASN83
J	GLY103
J	TRP137
J	ILE138
J	GLY139
J	GLY140
J	ALA157
J	ALA158
J	GLY174
J	ARG181
J	HOH903
J	HOH1001
J	HOH1018
K	LEU89
K	TYR109
K	ALA111
K	ASN163
K	THR175
K	PRO176

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BU1 K 196

Chain	Residue
K	HIS58

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACY K 197

Chain	Residue
K	ARG45
K	GLN49
K	VAL62

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY K 198

Chain	Residue
G	ALA43
G	GLU44
K	GLU44
K	LEU48
K	GLU51

site_id	DC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ACO L 195

Chain	Residue
I	GLU7
I	HOH624
K	GLY103
K	TRP137
K	GLY139
K	GLY140
K	ALA157
K	ALA158
K	GLY174
K	ARG178
K	LEU180
L	LEU89
L	TYR109
L	ALA111
L	HIS113
L	LEU115
L	ASN163
L	THR175
L	HOH211
L	HOH220
L	HOH364
L	HOH605

site_id	DC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ACO L 193

Chain	Residue
J	TYR109
J	HIS113
J	ASN145
J	ASN163
J	THR175
J	PRO176
J	HOH210
J	HOH669
L	ASN83
L	GLY103
L	PRO104
L	GLY139
L	GLY140
L	ALA157
L	ALA158
L	GLY174
L	ARG178
L	ARG181
L	HOH198
L	HOH304
L	HOH848

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL L 196

Chain	Residue
L	GLU42
L	ARG45
L	GLN49
L	VAL62
L	GLN63

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGgnVvInqgVtIGarSvVAanSvVnqdV

Chain	Residue	Details
A	ILE138-VAL166

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)