Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3NY2

Structure of the ubr-box of UBR2 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
B	0008270	molecular_function	zinc ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
C	0008270	molecular_function	zinc ion binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
D	0008270	molecular_function	zinc ion binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
E	0008270	molecular_function	zinc ion binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
F	0008270	molecular_function	zinc ion binding
F	0061630	molecular_function	ubiquitin protein ligase activity
F	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
G	0008270	molecular_function	zinc ion binding
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway
H	0008270	molecular_function	zinc ion binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0071596	biological_process	ubiquitin-dependent protein catabolic process via the N-end rule pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS99
A	CYS124
A	CYS127
A	CYS149

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS127
A	CYS151
A	CYS163
A	HIS166

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	CYS115
A	HIS133
A	HIS136
A	CYS112

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 4

Chain	Residue
B	CYS99
B	CYS124
B	CYS127
B	CYS149

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 5

Chain	Residue
B	CYS127
B	CYS151
B	CYS163
B	HIS166

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 6

Chain	Residue
B	CYS112
B	CYS115
B	HIS133
B	HIS136

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 7

Chain	Residue
C	CYS99
C	CYS124
C	CYS127
C	CYS149

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 8

Chain	Residue
C	CYS127
C	CYS151
C	CYS163
C	HIS166

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 9

Chain	Residue
C	CYS112
C	CYS115
C	HIS133
C	HIS136

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 10

Chain	Residue
D	CYS99
D	CYS124
D	CYS127
D	CYS149

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 11

Chain	Residue
D	CYS127
D	CYS151
D	CYS163
D	HIS166

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 12

Chain	Residue
D	CYS112
D	CYS115
D	HIS133
D	HIS136

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 13

Chain	Residue
E	CYS99
E	CYS124
E	CYS127
E	CYS149

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 14

Chain	Residue
E	CYS127
E	CYS151
E	CYS163
E	HIS166

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 15

Chain	Residue
E	CYS112
E	CYS115
E	HIS133
E	HIS136

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 16

Chain	Residue
F	CYS99
F	CYS124
F	CYS127
F	CYS149

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 17

Chain	Residue
F	CYS127
F	CYS151
F	CYS163
F	HIS166

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 18

Chain	Residue
F	CYS112
F	CYS115
F	HIS133
F	HIS136

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 19

Chain	Residue
G	CYS99
G	CYS124
G	CYS127
G	CYS149

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 20

Chain	Residue
G	CYS127
G	CYS151
G	CYS163
G	HIS166

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 21

Chain	Residue
G	CYS112
G	CYS115
G	HIS133
G	HIS136

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 22

Chain	Residue
H	CYS99
H	CYS124
H	CYS127
H	CYS149

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 23

Chain	Residue
H	CYS127
H	CYS151
H	CYS163
H	HIS166

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 24

Chain	Residue
H	CYS112
H	CYS115
H	HIS133
H	HIS136

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UM3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TDA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20835242","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NY3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38225265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)