3NRC
Crystal Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD+ and triclosan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD A 261 |
| Chain | Residue |
| A | GLY13 |
| A | ILE91 |
| A | ALA92 |
| A | LEU144 |
| A | THR145 |
| A | TYR146 |
| A | LYS163 |
| A | ALA189 |
| A | GLY190 |
| A | PRO191 |
| A | ILE192 |
| A | LEU15 |
| A | THR194 |
| A | ALA196 |
| A | TCL262 |
| A | HOH270 |
| A | HOH271 |
| A | HOH274 |
| A | HOH288 |
| A | HOH302 |
| A | SER19 |
| A | ILE20 |
| A | VAL40 |
| A | CYS62 |
| A | ASP63 |
| A | VAL64 |
| A | SER90 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TCL A 262 |
| Chain | Residue |
| A | ALA92 |
| A | ALA94 |
| A | LEU99 |
| A | TYR146 |
| A | TYR156 |
| A | ALA196 |
| A | NAD261 |
| site_id | AC3 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD B 261 |
| Chain | Residue |
| B | GLY13 |
| B | LEU15 |
| B | SER19 |
| B | ILE20 |
| B | VAL40 |
| B | CYS62 |
| B | ASP63 |
| B | VAL64 |
| B | ILE65 |
| B | SER90 |
| B | ILE91 |
| B | ALA92 |
| B | ILE118 |
| B | LEU144 |
| B | THR145 |
| B | TYR146 |
| B | LYS163 |
| B | ALA189 |
| B | GLY190 |
| B | PRO191 |
| B | ILE192 |
| B | THR194 |
| B | LEU195 |
| B | ALA196 |
| B | TCL262 |
| B | HOH267 |
| B | HOH287 |
| B | HOH299 |
| B | HOH300 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TCL B 262 |
| Chain | Residue |
| B | ALA92 |
| B | ALA94 |
| B | TYR146 |
| B | TYR156 |
| B | ALA196 |
| B | NAD261 |
