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3NQE

Crystal structure of the mutant L123N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0016831molecular_functioncarboxy-lyase activity
A0044205biological_process'de novo' UMP biosynthetic process
B0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
B0005829cellular_componentcytosol
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0016831molecular_functioncarboxy-lyase activity
B0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE BMP A 229
ChainResidue
AASP20
AGLY202
AARG203
AHOH249
AHOH251
AHOH263
AHOH437
AHOH438
AHOH439
AHOH440
BASP75
ALYS42
BILE76
BTHR79
AASP70
ALYS72
AASN123
AMET126
ASER127
APRO180
AGLN185

site_idAC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE BMP B 229
ChainResidue
AASP75
AILE76
ATHR79
BASP20
BLYS42
BASP70
BLYS72
BASN123
BMET126
BSER127
BPRO180
BGLN185
BGLY202
BARG203
BHOH242
BHOH319
BHOH444
BHOH446
BHOH447
BHOH448
BHOH449

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 230
ChainResidue
AASN210
AHOH268
AHOH294
AHOH436
BTHR159
BPRO161
BGLY186
BGLY187
BHOH426

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 231
ChainResidue
AARG144
AMET145
AHOH332

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN
ChainResidueDetails
AILE67-ASN80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor
ChainResidueDetails
ALYS72
BLYS72

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AASP20
BASP70
BSER127
BPRO180
BGLY202
BARG203
ALYS42
AASP70
ASER127
APRO180
AGLY202
AARG203
BASP20
BLYS42

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PDB entries from 2024-07-10

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