3NMS

Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
C	0005576	cellular_component	extracellular region
M	0005576	cellular_component	extracellular region

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"(Microbial infection) Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"18160402","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17051150","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17684013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2579379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	25
Details	Region: {"description":"Interaction with CFP/properdin","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Coordinates Mg(2+) for interaction with Complement factor B Bb fragment (CFB)","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	17
Details	Region: {"description":"Essential for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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