3NL6
The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
A | 0004789 | molecular_function | thiamine-phosphate diphosphorylase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0009228 | biological_process | thiamine biosynthetic process |
A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
B | 0004789 | molecular_function | thiamine-phosphate diphosphorylase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0009228 | biological_process | thiamine biosynthetic process |
B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004417 | molecular_function | hydroxyethylthiazole kinase activity |
C | 0004789 | molecular_function | thiamine-phosphate diphosphorylase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0009228 | biological_process | thiamine biosynthetic process |
C | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG A 541 |
Chain | Residue |
A | ACP799 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG C 541 |
Chain | Residue |
C | ASP340 |
C | VAL342 |
C | ACP899 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 541 |
Chain | Residue |
B | ACP999 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TPS A 2001 |
Chain | Residue |
A | HIS90 |
A | SER114 |
A | THR139 |
A | THR143 |
A | THR145 |
A | ILE179 |
A | GLY181 |
A | VAL209 |
A | SER210 |
A | TYR13 |
A | GLN43 |
A | ARG45 |
A | ASN75 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TPS C 2002 |
Chain | Residue |
C | TYR13 |
C | GLN43 |
C | ARG45 |
C | ASN75 |
C | HIS90 |
C | SER114 |
C | THR143 |
C | THR145 |
C | ILE179 |
C | GLY181 |
C | SER210 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TPS B 2006 |
Chain | Residue |
B | TYR13 |
B | GLN43 |
B | ARG45 |
B | HIS90 |
B | SER114 |
B | THR143 |
B | THR145 |
B | ILE179 |
B | GLY181 |
B | VAL209 |
B | SER210 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE ACP A 799 |
Chain | Residue |
A | ASN369 |
A | THR416 |
A | GLY417 |
A | GLU418 |
A | ASP420 |
A | GLY453 |
A | ILE455 |
A | MET458 |
A | ALA463 |
A | SER464 |
A | GLY465 |
A | CYS466 |
A | LEU468 |
A | TYR496 |
A | LYS497 |
A | MG541 |
site_id | AC8 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ACP C 899 |
Chain | Residue |
C | ASN369 |
C | THR416 |
C | GLY417 |
C | GLU418 |
C | ASP420 |
C | GLY453 |
C | ILE455 |
C | MET458 |
C | ALA463 |
C | GLY465 |
C | CYS466 |
C | LEU468 |
C | LYS497 |
C | MG541 |
site_id | AC9 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ACP B 999 |
Chain | Residue |
B | ASN369 |
B | THR416 |
B | GLY417 |
B | GLU418 |
B | ASP420 |
B | ILE455 |
B | MET458 |
B | ALA463 |
B | GLY465 |
B | CYS466 |
B | LEU468 |
B | TYR496 |
B | LYS497 |
B | MG541 |