3NKV

Crystal structure of Rab1b covalently modified with AMP at Y77

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE GNP A 400

Chain	Residue
A	SER17
A	GLU35
A	SER36
A	SER39
A	THR40
A	GLY66
A	ASN121
A	LYS122
A	ASP124
A	LEU125
A	SER151
A	GLY18
A	ALA152
A	LYS153
A	HOH187
A	HOH189
A	HOH191
A	HOH208
A	HOH211
A	HOH218
A	HOH291
A	MG500
A	VAL19
A	GLY20
A	LYS21
A	SER22
A	CYS23
A	TYR33
A	THR34

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 500

Chain	Residue
A	SER22
A	THR40
A	HOH189
A	HOH218
A	GNP400

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BA A 175

Chain	Residue
A	ILE41
A	VAL43
A	ASP44
A	HOH261

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AMP A 600

Chain	Residue
A	VAL43
A	PHE45
A	GLN60
A	TRP62
A	TYR77
A	HOH281

---

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GNP B 400

Chain	Residue
B	SER17
B	GLY18
B	VAL19
B	GLY20
B	LYS21
B	SER22
B	CYS23
B	TYR33
B	GLU35
B	THR40
B	GLY66
B	ASN121
B	LYS122
B	ASP124
B	LEU125
B	SER151
B	ALA152
B	LYS153
B	HOH181
B	HOH185
B	HOH199
B	HOH204
B	HOH212
B	HOH215
B	HOH227
B	HOH278
B	MG500

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 500

Chain	Residue
B	SER22
B	THR40
B	HOH185
B	HOH199
B	GNP400

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BA B 175

Chain	Residue
A	GLU4
A	ASP6
A	THR56
B	ASP132
B	THR134
B	HOH187
B	HOH228
B	HOH301

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AMP B 600

Chain	Residue
B	PHE45
B	TRP62
B	TYR77
B	HOH176
B	HOH216
B	HOH256

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKscL

Chain	Residue	Details
A	LEU11-LEU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20064470, ECO:0000269|PubMed:20651120, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:3JZA, ECO:0007744|PDB:3NKV, ECO:0007744|PDB:4HLQ, ECO:0007744|PDB:4I1O, ECO:0007744|PDB:5SZH, ECO:0007744|PDB:5SZK

Chain	Residue	Details
A	GLY15
B	GLY15

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20651120, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:3NKV, ECO:0007744|PDB:4HLQ, ECO:0007744|PDB:5SZH, ECO:0007744|PDB:5SZK

Chain	Residue	Details
A	TYR33
B	TYR33

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20651120, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:3NKV, ECO:0007744|PDB:5SZH, ECO:0007744|PDB:5SZK

Chain	Residue	Details
A	ASP63
B	ASP63

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20651120, ECO:0000269|PubMed:23236136, ECO:0000269|PubMed:27552051, ECO:0007744|PDB:3NKV, ECO:0007744|PDB:4HLQ, ECO:0007744|PDB:4I1O, ECO:0007744|PDB:5SZH, ECO:0007744|PDB:5SZK

Chain	Residue	Details
A	ASN121
A	SER151
B	ASN121
B	SER151

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-(2-cholinephosphoryl)serine => ECO:0000269|PubMed:21822290, ECO:0000269|PubMed:22158903, ECO:0000269|PubMed:22307087

Chain	Residue	Details
A	SER76
B	SER76

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: (Microbial infection) O-AMP-tyrosine => ECO:0000269|PubMed:20651120

Chain	Residue	Details
A	TYR77
B	TYR77

---