3NGO

Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004535	molecular_function	poly(A)-specific ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 556

Chain	Residue
A	ASP410
A	ASN412
A	ILE488
A	HIS529
B	DA659

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 557

Chain	Residue
B	DA658
B	DA659
A	GLU240
A	HOH560
A	HOH587
A	HOH624

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DV2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NGQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20628353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27013054","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DV2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---