3NGN

Crystal structure of the human CNOT6L nuclease domain in complex with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004535	molecular_function	poly(A)-specific ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP A 556

Chain	Residue
A	GLU240
A	HIS529
A	HOH592
A	HOH614
A	HIS360
A	TRP363
A	PRO365
A	LYS371
A	ASP410
A	ASN412
A	ASN479
A	PHE484

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AMP A 557

Chain	Residue
A	TRP174
A	SER188
A	THR190
A	ILE271
A	MET272
A	SER273
A	GLU276
A	GLN535
A	HOH558

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:20628353, ECO:0000305|PubMed:27013054

Chain	Residue	Details
A	ASP410

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:3NGN, ECO:0007744|PDB:5DV2

Chain	Residue	Details
A	GLU240
A	HIS360
A	ASN412
A	ASN479

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGN

Chain	Residue	Details
A	GLU276

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20628353

Chain	Residue	Details
A	PRO365

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0007744|PDB:3NGQ

Chain	Residue	Details
A	ASP410

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054, ECO:0007744|PDB:5DV2

Chain	Residue	Details
A	PHE484

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