3NEV

Crystal structure of YagE, a prophage protein from E. coli K12 in complex with KDGal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016829	molecular_function	lyase activity
A	0042802	molecular_function	identical protein binding
A	0046176	biological_process	aldonic acid catabolic process
A	0047440	molecular_function	2-dehydro-3-deoxy-D-pentonate aldolase activity
A	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016829	molecular_function	lyase activity
B	0042802	molecular_function	identical protein binding
B	0046176	biological_process	aldonic acid catabolic process
B	0047440	molecular_function	2-dehydro-3-deoxy-D-pentonate aldolase activity
B	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016829	molecular_function	lyase activity
C	0042802	molecular_function	identical protein binding
C	0046176	biological_process	aldonic acid catabolic process
C	0047440	molecular_function	2-dehydro-3-deoxy-D-pentonate aldolase activity
C	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016829	molecular_function	lyase activity
D	0042802	molecular_function	identical protein binding
D	0046176	biological_process	aldonic acid catabolic process
D	0047440	molecular_function	2-dehydro-3-deoxy-D-pentonate aldolase activity
D	0061677	molecular_function	2-dehydro-3-deoxy-D-gluconate aldolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 2

Chain	Residue
A	LEU54
A	TYR145
A	PHE60
A	ARG68
A	GLY88
A	THR89
A	GLY90
A	VAL113
A	VAL114
A	ILE115

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	ASN126
A	ARG129
A	HOH339
A	HOH449
B	SER289

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE RSH A 1

Chain	Residue
A	PRO20
A	PHE52
A	GLY55
A	SER56
A	GLY57
A	TYR145
A	PHE147
A	LYS174
A	THR176
A	GLY202
A	ILE219
A	SER220
A	ALA221

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 3

Chain	Residue
B	LEU54
B	GLY55
B	PHE60
B	GLY88
B	GLY90
B	VAL113
B	VAL114
B	ILE115

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 4

Chain	Residue
A	PRO286
A	PRO287
A	ALA288
B	ASN126
B	ARG129
B	TYR130
B	GLN133

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE RSH B 2

Chain	Residue
B	PRO20
B	PHE52
B	GLY55
B	SER56
B	GLY57
B	TYR145
B	LYS174
B	THR176
B	GLY202
B	ILE219
B	SER220
B	ALA221

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO C 1

Chain	Residue
C	LEU54
C	PHE60
C	ARG68
C	GLY88
C	THR89
C	GLY90
C	VAL113
C	VAL114
C	ILE115

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 7

Chain	Residue
C	HIS283
C	VAL284
C	ALA288
C	PRO290
C	HOH372
D	ARG129

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE RSH C 3

Chain	Residue
C	PRO20
C	PHE52
C	GLY55
C	SER56
C	GLY57
C	TYR145
C	LYS174
C	THR176
C	GLY202
C	TYR203
C	ILE219
C	SER220
C	ALA221
C	HOH392

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO D 6

Chain	Residue
D	LEU54
D	GLY55
D	PHE60
D	GLY88
D	GLY90
D	VAL113
D	VAL114
D	ILE115

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE EDO D 8

Chain	Residue
D	HOH332
D	HOH337
D	HOH366
D	HOH456
C	ALA125
C	ARG129
C	HOH454
D	ASP262
D	ASP292
D	ARG295
D	HOH313

---

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE RSH D 4

Chain	Residue
D	PRO20
D	PHE52
D	GLY55
D	SER56
D	GLY57
D	TYR145
D	PHE147
D	LYS174
D	THR176
D	GLY202
D	ILE219
D	SER220
D	ALA221
D	HOH453
D	HOH480

---

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. GLFflGSGGEFsqlgaeE

Chain	Residue	Details
A	GLY50-GLU67

---

site_id	PS00666
Number of Residues	32
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNFPalTgqdLtpalvktladsrsnIiGIKDT

Chain	Residue	Details
A	TYR145-THR176

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:21294156

Chain	Residue	Details
A	ASP49
A	ILE112
B	ASP49
B	ILE112
C	ASP49
C	ILE112
D	ASP49
D	ILE112

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:21294156

Chain	Residue	Details
A	VAL138
B	VAL138
C	VAL138
D	VAL138

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000305|PubMed:21294156

Chain	Residue	Details
A	ARG167
B	ARG167
C	ARG167
D	ARG167

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