Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE ROC A 101 |
| Chain | Residue |
| A | ARG9 |
| A | ILE51 |
| A | THR81 |
| A | PRO82 |
| A | ILE85 |
| A | HOH119 |
| A | HOH570 |
| B | ARG9 |
| B | ASP26 |
| B | GLY28 |
| B | ALA29 |
| A | ASP26 |
| B | ASP30 |
| B | ASP31 |
| B | GLY49 |
| B | GLY50 |
| B | ILE51 |
| B | THR81 |
| B | PRO82 |
| B | VAL83 |
| B | ILE85 |
| B | HOH103 |
| A | GLY28 |
| B | HOH107 |
| B | HOH153 |
| C | TRP6 |
| A | ALA29 |
| A | ASP30 |
| A | ASP31 |
| A | ILE48 |
| A | GLY49 |
| A | GLY50 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 102 |
| Chain | Residue |
| A | LYS15 |
| A | ILE16 |
| A | GLY18 |
| A | ILE64 |
| B | GLY18 |
| B | DMS101 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 1007 |
| Chain | Residue |
| A | THR13 |
| A | GLU66 |
| A | ALA68 |
| A | GLY69 |
| A | NA1015 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1010 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1012 |
| Chain | Residue |
| A | GLN3 |
| A | ILE4 |
| A | THR5 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 1015 |
| Chain | Residue |
| A | GLY69 |
| A | HOH112 |
| A | ACT1007 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 1017 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1021 |
| Chain | Residue |
| A | LYS44 |
| A | LYS46 |
| A | GLN59 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS B 101 |
| Chain | Residue |
| A | LYS15 |
| A | GLY18 |
| A | DMS102 |
| B | LYS15 |
| B | ILE16 |
| B | GLY17 |
| B | GLY18 |
| B | ILE64 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1001 |
| Chain | Residue |
| B | LYS46 |
| B | MET47 |
| B | HOH104 |
| B | HOH212 |
| D | HOH107 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1003 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1005 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA B 1014 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 1016 |
| Chain | Residue |
| B | LEU11 |
| B | VAL12 |
| B | THR13 |
| B | HOH576 |
| C | TRP42 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 1020 |
| Chain | Residue |
| A | HIS70 |
| A | ILE94 |
| B | PHE100 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS C 100 |
| Chain | Residue |
| C | LYS14 |
| C | GLY16 |
| C | GLY17 |
| C | ILE63 |
| D | GLY17 |
| D | DMS101 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS C 101 |
| Chain | Residue |
| C | MET36 |
| C | SER37 |
| D | PRO39 |
| D | GLY40 |
| D | HOH203 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 1006 |
| Chain | Residue |
| A | LYS71 |
| B | LYS15 |
| C | LYS55 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 1008 |
| Chain | Residue |
| C | THR4 |
| C | TRP6 |
| C | HOH301 |
| D | THR91 |
| D | GLY94 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 1013 |
| Chain | Residue |
| C | HOH578 |
| D | GLY51 |
| D | HOH541 |
| C | PRO79 |
| site_id | CC3 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE ROC D 100 |
| Chain | Residue |
| C | ARG8 |
| C | ASP25 |
| C | GLY27 |
| C | ALA28 |
| C | ASP29 |
| C | ASP30 |
| C | VAL32 |
| C | ILE47 |
| C | GLY48 |
| C | GLY49 |
| C | ILE50 |
| C | THR80 |
| C | PRO81 |
| C | ILE84 |
| C | HOH129 |
| C | HOH573 |
| D | ASP25 |
| D | GLY27 |
| D | ALA28 |
| D | ASP29 |
| D | ASP30 |
| D | VAL32 |
| D | ILE47 |
| D | GLY48 |
| D | GLY49 |
| D | ILE50 |
| D | THR80 |
| D | PRO81 |
| D | ILE84 |
| D | HOH115 |
| D | HOH150 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMS D 101 |
| Chain | Residue |
| C | GLY17 |
| C | DMS100 |
| D | LYS14 |
| D | ILE15 |
| D | GLY16 |
| D | GLY17 |
| D | ILE63 |
| D | GLU65 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA23-ILE34 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
