Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
A | 0006508 | biological_process | proteolysis |
B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
B | 0006508 | biological_process | proteolysis |
C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
C | 0006508 | biological_process | proteolysis |
D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
D | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE ROC A 101 |
Chain | Residue |
A | ARG9 |
A | ILE51 |
A | THR81 |
A | PRO82 |
A | ILE85 |
A | HOH119 |
A | HOH570 |
B | ARG9 |
B | ASP26 |
B | GLY28 |
B | ALA29 |
A | ASP26 |
B | ASP30 |
B | ASP31 |
B | GLY49 |
B | GLY50 |
B | ILE51 |
B | THR81 |
B | PRO82 |
B | VAL83 |
B | ILE85 |
B | HOH103 |
A | GLY28 |
B | HOH107 |
B | HOH153 |
C | TRP6 |
A | ALA29 |
A | ASP30 |
A | ASP31 |
A | ILE48 |
A | GLY49 |
A | GLY50 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS A 102 |
Chain | Residue |
A | LYS15 |
A | ILE16 |
A | GLY18 |
A | ILE64 |
B | GLY18 |
B | DMS101 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT A 1007 |
Chain | Residue |
A | THR13 |
A | GLU66 |
A | ALA68 |
A | GLY69 |
A | NA1015 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL A 1010 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1012 |
Chain | Residue |
A | GLN3 |
A | ILE4 |
A | THR5 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 1015 |
Chain | Residue |
A | GLY69 |
A | HOH112 |
A | ACT1007 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACT A 1017 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 1021 |
Chain | Residue |
A | LYS44 |
A | LYS46 |
A | GLN59 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS B 101 |
Chain | Residue |
A | LYS15 |
A | GLY18 |
A | DMS102 |
B | LYS15 |
B | ILE16 |
B | GLY17 |
B | GLY18 |
B | ILE64 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 1001 |
Chain | Residue |
B | LYS46 |
B | MET47 |
B | HOH104 |
B | HOH212 |
D | HOH107 |
site_id | BC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B 1003 |
site_id | BC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B 1005 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE NA B 1014 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT B 1016 |
Chain | Residue |
B | LEU11 |
B | VAL12 |
B | THR13 |
B | HOH576 |
C | TRP42 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA B 1020 |
Chain | Residue |
A | HIS70 |
A | ILE94 |
B | PHE100 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS C 100 |
Chain | Residue |
C | LYS14 |
C | GLY16 |
C | GLY17 |
C | ILE63 |
D | GLY17 |
D | DMS101 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS C 101 |
Chain | Residue |
C | MET36 |
C | SER37 |
D | PRO39 |
D | GLY40 |
D | HOH203 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 1006 |
Chain | Residue |
A | LYS71 |
B | LYS15 |
C | LYS55 |
site_id | CC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT C 1008 |
Chain | Residue |
C | THR4 |
C | TRP6 |
C | HOH301 |
D | THR91 |
D | GLY94 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL C 1013 |
Chain | Residue |
C | HOH578 |
D | GLY51 |
D | HOH541 |
C | PRO79 |
site_id | CC3 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE ROC D 100 |
Chain | Residue |
C | ARG8 |
C | ASP25 |
C | GLY27 |
C | ALA28 |
C | ASP29 |
C | ASP30 |
C | VAL32 |
C | ILE47 |
C | GLY48 |
C | GLY49 |
C | ILE50 |
C | THR80 |
C | PRO81 |
C | ILE84 |
C | HOH129 |
C | HOH573 |
D | ASP25 |
D | GLY27 |
D | ALA28 |
D | ASP29 |
D | ASP30 |
D | VAL32 |
D | ILE47 |
D | GLY48 |
D | GLY49 |
D | ILE50 |
D | THR80 |
D | PRO81 |
D | ILE84 |
D | HOH115 |
D | HOH150 |
site_id | CC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS D 101 |
Chain | Residue |
C | GLY17 |
C | DMS100 |
D | LYS14 |
D | ILE15 |
D | GLY16 |
D | GLY17 |
D | ILE63 |
D | GLU65 |
Functional Information from PROSITE/UniProt
site_id | PS00141 |
Number of Residues | 12 |
Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
Chain | Residue | Details |
A | ALA23-ILE34 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP26 | |
B | ASP26 | |
C | ASP25 | |
D | ASP25 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Cleavage; by viral protease => ECO:0000250 |
Chain | Residue | Details |
A | PHE100 | |
B | PHE100 | |
C | PHE99 | |
D | PHE99 | |