3ND7
Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0015937 | biological_process | coenzyme A biosynthetic process |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0015937 | biological_process | coenzyme A biosynthetic process |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004595 | molecular_function | pantetheine-phosphate adenylyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0015937 | biological_process | coenzyme A biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PNY A 501 |
| Chain | Residue |
| A | GLY9 |
| A | HOH200 |
| C | GLU135 |
| A | SER10 |
| A | GLN73 |
| A | LEU74 |
| A | THR75 |
| A | TYR99 |
| A | MET106 |
| A | ASN107 |
| A | HOH193 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PNY B 502 |
| Chain | Residue |
| B | PHE37 |
| B | GLN73 |
| B | LEU74 |
| B | THR75 |
| B | TYR99 |
| B | ILE103 |
| B | MET106 |
| B | ASN107 |
| B | HOH172 |
| B | HOH173 |
| F | GLU135 |
| F | PHE139 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PNY C 503 |
| Chain | Residue |
| C | GLN73 |
| C | LEU74 |
| C | THR75 |
| C | ARG89 |
| C | TYR99 |
| C | ILE103 |
| C | MET106 |
| C | ASN107 |
| C | HOH182 |
| E | GLU135 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PNY D 504 |
| Chain | Residue |
| B | LEU132 |
| B | GLU135 |
| D | PRO8 |
| D | GLN73 |
| D | LEU74 |
| D | THR75 |
| D | TYR99 |
| D | ILE103 |
| D | MET106 |
| D | ASN107 |
| D | HOH178 |
| D | HOH192 |
| D | HOH199 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PNY E 505 |
| Chain | Residue |
| A | GLU135 |
| E | GLY9 |
| E | GLN73 |
| E | LEU74 |
| E | THR75 |
| E | ARG89 |
| E | TYR99 |
| E | MET106 |
| E | ASN107 |
| E | HOH179 |
| E | HOH225 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PNY F 506 |
| Chain | Residue |
| D | GLU135 |
| F | LEU74 |
| F | THR75 |
| F | TYR99 |
| F | MET106 |
| F | ASN107 |
| F | HOH172 |
| F | HOH182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21912874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ND6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21912874","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3ND7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00151","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
