3NC2

X-ray structure of ketohexokinase with a quinazoline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004454	molecular_function	ketohexokinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006000	biological_process	fructose metabolic process
A	0009744	biological_process	response to sucrose
A	0009749	biological_process	response to glucose
A	0009750	biological_process	response to fructose
A	0010043	biological_process	response to zinc ion
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032868	biological_process	response to insulin
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046835	biological_process	carbohydrate phosphorylation
A	0070061	molecular_function	fructose binding
A	0070062	cellular_component	extracellular exosome
A	0070873	biological_process	regulation of glycogen metabolic process
B	0000166	molecular_function	nucleotide binding
B	0004454	molecular_function	ketohexokinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006000	biological_process	fructose metabolic process
B	0009744	biological_process	response to sucrose
B	0009749	biological_process	response to glucose
B	0009750	biological_process	response to fructose
B	0010043	biological_process	response to zinc ion
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032868	biological_process	response to insulin
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046835	biological_process	carbohydrate phosphorylation
B	0070061	molecular_function	fructose binding
B	0070062	cellular_component	extracellular exosome
B	0070873	biological_process	regulation of glycogen metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE QUZ A 299

Chain	Residue
A	ALA226
A	GLU227

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	ARG108
A	GLU173
A	THR253
A	GLY255
A	ALA256
A	GLY257
A	ASP258

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE QUZ B 299

Chain	Residue
B	GLU227
B	PRO246
B	CYS289

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 300

Chain	Residue
B	ARG78
B	ARG79
B	GLY293
B	PHE294

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
A	ARG31
B	LEU11
B	HIS113
B	ARG141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19237742","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2HW1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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