3NBS

Crystal structure of dimeric cytochrome c from horse heart

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0006915	biological_process	apoptotic process
A	0008289	molecular_function	lipid binding
A	0009055	molecular_function	electron transfer activity
A	0018063	biological_process	cytochrome c-heme linkage
A	0020037	molecular_function	heme binding
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0046872	molecular_function	metal ion binding
A	0070069	cellular_component	cytochrome complex
A	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0006915	biological_process	apoptotic process
B	0008289	molecular_function	lipid binding
B	0009055	molecular_function	electron transfer activity
B	0018063	biological_process	cytochrome c-heme linkage
B	0020037	molecular_function	heme binding
B	0042802	molecular_function	identical protein binding
B	0043065	biological_process	positive regulation of apoptotic process
B	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
B	0046872	molecular_function	metal ion binding
B	0070069	cellular_component	cytochrome complex
B	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0006915	biological_process	apoptotic process
C	0008289	molecular_function	lipid binding
C	0009055	molecular_function	electron transfer activity
C	0018063	biological_process	cytochrome c-heme linkage
C	0020037	molecular_function	heme binding
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
C	0046872	molecular_function	metal ion binding
C	0070069	cellular_component	cytochrome complex
C	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0006915	biological_process	apoptotic process
D	0008289	molecular_function	lipid binding
D	0009055	molecular_function	electron transfer activity
D	0018063	biological_process	cytochrome c-heme linkage
D	0020037	molecular_function	heme binding
D	0042802	molecular_function	identical protein binding
D	0043065	biological_process	positive regulation of apoptotic process
D	0043280	biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
D	0046872	molecular_function	metal ion binding
D	0070069	cellular_component	cytochrome complex
D	2001056	biological_process	positive regulation of cysteine-type endopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 105

Chain	Residue
A	LYS13
A	THR49
A	ASN52
A	TRP59
A	TYR67
A	THR78
A	HOH201
A	HOH358
A	HOH403
B	PHE82
B	LEU94
A	CYS14
A	CYS17
A	HIS18
A	THR28
A	GLY29
A	THR40
A	GLY41
A	TYR48

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PG4 A 2002

Chain	Residue
A	LYS55
A	ILE57
A	GLU66
A	LYS73
A	TYR74
A	PRO76
D	LYS55
D	GLU66
D	LYS73
D	TYR74
D	PRO76

---

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM B 105

Chain	Residue
A	PHE82
A	LEU94
B	LYS13
B	CYS14
B	CYS17
B	HIS18
B	THR28
B	THR40
B	GLY41
B	TYR48
B	THR49
B	ASN52
B	TRP59
B	TYR67
B	THR78
B	HOH202
B	HOH207
B	HOH320
B	PEG2004

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 2004

Chain	Residue
A	GLN16
A	THR28
B	GLN16
B	HEC105

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM C 105

Chain	Residue
C	LYS13
C	CYS14
C	CYS17
C	HIS18
C	THR28
C	ARG38
C	THR40
C	GLY41
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	TYR67
C	THR78
C	HOH203
C	HOH362
C	HOH441
D	MET80
D	PHE82
D	LEU94

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 C 1001

Chain	Residue
A	HOH420
B	TYR97
B	LYS100
B	GLU104
C	TYR97
C	LYS100
C	GLU104
D	LYS7
D	HOH297

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PG4 C 2001

Chain	Residue
B	LYS55
B	GLU66
B	LYS73
B	TYR74
B	PRO76
B	HOH389
C	LYS55
C	GLU66
C	LYS73
C	TYR74
C	PRO76

---

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM D 105

Chain	Residue
D	HIS18
D	THR28
D	THR40
D	GLY41
D	TYR48
D	THR49
D	ASN52
D	TRP59
D	TYR67
D	THR78
D	HOH204
D	HOH252
D	HOH300
D	PEG2003
C	PHE82
C	ILE85
C	LEU94
D	LYS13
D	CYS14
D	CYS17

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 1002

Chain	Residue
A	TYR97
A	LYS100
A	GLU104
B	HOH345
C	LYS7
C	HOH271
D	TYR97
D	LYS100
D	GLU104

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG D 2003

Chain	Residue
C	THR28
D	GLN16
D	HEC105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: covalent

Chain	Residue	Details
A	CYS14
A	CYS17
B	CYS14
B	CYS17
C	CYS14
C	CYS17
D	CYS14
D	CYS17

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:5545094

Chain	Residue	Details
A	HIS18
B	HIS18
C	HIS18
D	HIS18

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: axial binding residue

Chain	Residue	Details
A	MET80
B	MET80
C	MET80
D	MET80

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylglycine => ECO:0000269|PubMed:14469771

Chain	Residue	Details
A	GLY1
B	GLY1
C	GLY1
D	GLY1

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62894

Chain	Residue	Details
A	TYR48
A	TYR97
B	TYR48
B	TYR97
C	TYR48
C	TYR97
D	TYR48
D	TYR97

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS55
B	LYS55
C	LYS55
D	LYS55

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS72
B	LYS72
C	LYS72
D	LYS72

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897

Chain	Residue	Details
A	LYS99
B	LYS99
C	LYS99
D	LYS99

---