3NBS
Crystal structure of dimeric cytochrome c from horse heart
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0022904 | biological_process | respiratory electron transport chain |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070069 | cellular_component | cytochrome complex |
| A | 0097190 | biological_process | apoptotic signaling pathway |
| B | 0005515 | molecular_function | protein binding |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070069 | cellular_component | cytochrome complex |
| B | 0097190 | biological_process | apoptotic signaling pathway |
| C | 0005515 | molecular_function | protein binding |
| C | 0005758 | cellular_component | mitochondrial intermembrane space |
| C | 0005829 | cellular_component | cytosol |
| C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| C | 0006915 | biological_process | apoptotic process |
| C | 0008289 | molecular_function | lipid binding |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070069 | cellular_component | cytochrome complex |
| C | 0097190 | biological_process | apoptotic signaling pathway |
| D | 0005515 | molecular_function | protein binding |
| D | 0005758 | cellular_component | mitochondrial intermembrane space |
| D | 0005829 | cellular_component | cytosol |
| D | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| D | 0006915 | biological_process | apoptotic process |
| D | 0008289 | molecular_function | lipid binding |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0020037 | molecular_function | heme binding |
| D | 0022904 | biological_process | respiratory electron transport chain |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070069 | cellular_component | cytochrome complex |
| D | 0097190 | biological_process | apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM A 105 |
| Chain | Residue |
| A | LYS13 |
| A | THR49 |
| A | ASN52 |
| A | TRP59 |
| A | TYR67 |
| A | THR78 |
| A | HOH201 |
| A | HOH358 |
| A | HOH403 |
| B | PHE82 |
| B | LEU94 |
| A | CYS14 |
| A | CYS17 |
| A | HIS18 |
| A | THR28 |
| A | GLY29 |
| A | THR40 |
| A | GLY41 |
| A | TYR48 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PG4 A 2002 |
| Chain | Residue |
| A | LYS55 |
| A | ILE57 |
| A | GLU66 |
| A | LYS73 |
| A | TYR74 |
| A | PRO76 |
| D | LYS55 |
| D | GLU66 |
| D | LYS73 |
| D | TYR74 |
| D | PRO76 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEM B 105 |
| Chain | Residue |
| A | PHE82 |
| A | LEU94 |
| B | LYS13 |
| B | CYS14 |
| B | CYS17 |
| B | HIS18 |
| B | THR28 |
| B | THR40 |
| B | GLY41 |
| B | TYR48 |
| B | THR49 |
| B | ASN52 |
| B | TRP59 |
| B | TYR67 |
| B | THR78 |
| B | HOH202 |
| B | HOH207 |
| B | HOH320 |
| B | PEG2004 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 2004 |
| Chain | Residue |
| A | GLN16 |
| A | THR28 |
| B | GLN16 |
| B | HEC105 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM C 105 |
| Chain | Residue |
| C | LYS13 |
| C | CYS14 |
| C | CYS17 |
| C | HIS18 |
| C | THR28 |
| C | ARG38 |
| C | THR40 |
| C | GLY41 |
| C | TYR48 |
| C | THR49 |
| C | ASN52 |
| C | TRP59 |
| C | TYR67 |
| C | THR78 |
| C | HOH203 |
| C | HOH362 |
| C | HOH441 |
| D | MET80 |
| D | PHE82 |
| D | LEU94 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1001 |
| Chain | Residue |
| A | HOH420 |
| B | TYR97 |
| B | LYS100 |
| B | GLU104 |
| C | TYR97 |
| C | LYS100 |
| C | GLU104 |
| D | LYS7 |
| D | HOH297 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PG4 C 2001 |
| Chain | Residue |
| B | LYS55 |
| B | GLU66 |
| B | LYS73 |
| B | TYR74 |
| B | PRO76 |
| B | HOH389 |
| C | LYS55 |
| C | GLU66 |
| C | LYS73 |
| C | TYR74 |
| C | PRO76 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE HEM D 105 |
| Chain | Residue |
| D | HIS18 |
| D | THR28 |
| D | THR40 |
| D | GLY41 |
| D | TYR48 |
| D | THR49 |
| D | ASN52 |
| D | TRP59 |
| D | TYR67 |
| D | THR78 |
| D | HOH204 |
| D | HOH252 |
| D | HOH300 |
| D | PEG2003 |
| C | PHE82 |
| C | ILE85 |
| C | LEU94 |
| D | LYS13 |
| D | CYS14 |
| D | CYS17 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1002 |
| Chain | Residue |
| A | TYR97 |
| A | LYS100 |
| A | GLU104 |
| B | HOH345 |
| C | LYS7 |
| C | HOH271 |
| D | TYR97 |
| D | LYS100 |
| D | GLU104 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 2003 |
| Chain | Residue |
| C | THR28 |
| D | GLN16 |
| D | HEC105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"covalent"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"5545094","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"14469771","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62894","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
