3N9W
Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) in complex with 1,2-Propanediol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| A | 0070567 | molecular_function | cytidylyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050518 | molecular_function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity |
| B | 0070567 | molecular_function | cytidylyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGO A 3002 |
| Chain | Residue |
| A | ASP106 |
| A | ARG109 |
| A | ALA163 |
| A | THR165 |
| A | ASP190 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGO A 3003 |
| Chain | Residue |
| A | ALA135 |
| A | ARG138 |
| A | HIS162 |
| A | ALA209 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGR B 3001 |
| Chain | Residue |
| A | ASP139 |
| A | THR140 |
| B | ASP106 |
| B | ARG109 |
| B | ALA163 |
| B | LYS213 |
Functional Information from PROSITE/UniProt
| site_id | PS01295 |
| Number of Residues | 8 |
| Details | ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR |
| Chain | Residue | Details |
| A | VAL102-ARG109 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:11427897 |
| Chain | Residue | Details |
| A | ARG20 | |
| A | LYS27 | |
| B | ARG20 | |
| B | LYS27 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897 |
| Chain | Residue | Details |
| A | ARG157 | |
| A | LYS213 | |
| B | ARG157 | |
| B | LYS213 |
