3N9R
Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(4-hydroxybutyl)-phosphoglycolohydroxamic acid, a competitive inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016832 | molecular_function | aldehyde-lyase activity |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016832 | molecular_function | aldehyde-lyase activity |
| B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| e | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| e | 0005975 | biological_process | carbohydrate metabolic process |
| e | 0006096 | biological_process | glycolytic process |
| e | 0008270 | molecular_function | zinc ion binding |
| e | 0016832 | molecular_function | aldehyde-lyase activity |
| e | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| j | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| j | 0005975 | biological_process | carbohydrate metabolic process |
| j | 0006096 | biological_process | glycolytic process |
| j | 0008270 | molecular_function | zinc ion binding |
| j | 0016832 | molecular_function | aldehyde-lyase activity |
| j | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| K | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| K | 0005975 | biological_process | carbohydrate metabolic process |
| K | 0006096 | biological_process | glycolytic process |
| K | 0008270 | molecular_function | zinc ion binding |
| K | 0016832 | molecular_function | aldehyde-lyase activity |
| K | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| P | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| P | 0005975 | biological_process | carbohydrate metabolic process |
| P | 0006096 | biological_process | glycolytic process |
| P | 0008270 | molecular_function | zinc ion binding |
| P | 0016832 | molecular_function | aldehyde-lyase activity |
| P | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| U | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| U | 0005975 | biological_process | carbohydrate metabolic process |
| U | 0006096 | biological_process | glycolytic process |
| U | 0008270 | molecular_function | zinc ion binding |
| U | 0016832 | molecular_function | aldehyde-lyase activity |
| U | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| Z | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| Z | 0005975 | biological_process | carbohydrate metabolic process |
| Z | 0006096 | biological_process | glycolytic process |
| Z | 0008270 | molecular_function | zinc ion binding |
| Z | 0016832 | molecular_function | aldehyde-lyase activity |
| Z | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 308 |
| Chain | Residue |
| A | HIS83 |
| A | HIS180 |
| A | HIS210 |
| A | TD3311 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA A 309 |
| Chain | Residue |
| A | HIS210 |
| A | LYS251 |
| A | ASN253 |
| A | GLN47 |
| A | HIS80 |
| A | ASP82 |
| A | MET102 |
| A | GLU132 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 310 |
| Chain | Residue |
| A | ASP104 |
| A | SER106 |
| A | GLU134 |
| A | HOH328 |
| A | HOH657 |
| A | HOH932 |
| A | HOH1126 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TD3 A 311 |
| Chain | Residue |
| A | HIS83 |
| A | HIS180 |
| A | GLY181 |
| A | LYS184 |
| A | HIS210 |
| A | GLY211 |
| A | ALA212 |
| A | SER213 |
| A | ASN253 |
| A | ASP255 |
| A | THR256 |
| A | ZN308 |
| A | HOH374 |
| A | HOH807 |
| A | HOH2493 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 308 |
| Chain | Residue |
| B | HIS83 |
| B | HIS180 |
| B | HIS210 |
| B | TD3311 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA B 309 |
| Chain | Residue |
| B | GLN47 |
| B | HIS80 |
| B | ASP82 |
| B | MET102 |
| B | GLU132 |
| B | HIS210 |
| B | LYS251 |
| B | ASN253 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL B 310 |
| Chain | Residue |
| B | ASP104 |
| B | SER106 |
| B | GLU134 |
| B | HOH336 |
| B | HOH814 |
| B | HOH971 |
| B | HOH1010 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TD3 B 311 |
| Chain | Residue |
| B | HIS83 |
| B | HIS180 |
| B | GLY181 |
| B | LYS184 |
| B | HIS210 |
| B | GLY211 |
| B | ALA212 |
| B | SER213 |
| B | ASN253 |
| B | ASP255 |
| B | THR256 |
| B | ZN308 |
| B | HOH641 |
| B | HOH779 |
| B | HOH1770 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN K 308 |
| Chain | Residue |
| K | HIS83 |
| K | HIS180 |
| K | HIS210 |
| K | TD3311 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA K 309 |
| Chain | Residue |
| K | GLN47 |
| K | HIS80 |
| K | ASP82 |
| K | MET102 |
| K | GLU132 |
| K | HIS210 |
| K | LYS251 |
| K | ASN253 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL K 310 |
| Chain | Residue |
| K | ASP104 |
| K | SER106 |
| K | GLU134 |
| K | HOH330 |
| K | HOH589 |
| K | HOH1424 |
| K | HOH1565 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TD3 K 311 |
| Chain | Residue |
| K | HOH2453 |
| K | HIS83 |
| K | HIS180 |
| K | GLY181 |
| K | LYS184 |
| K | HIS210 |
| K | GLY211 |
| K | ALA212 |
| K | SER213 |
| K | ASN253 |
| K | ASP255 |
| K | THR256 |
| K | ZN308 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN P 308 |
| Chain | Residue |
| P | HIS83 |
| P | HIS180 |
| P | HIS210 |
| P | TD3311 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA P 309 |
| Chain | Residue |
| P | GLN47 |
| P | HIS80 |
| P | ASP82 |
| P | MET102 |
| P | GLU132 |
| P | HIS210 |
| P | LYS251 |
| P | ASN253 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL P 310 |
| Chain | Residue |
| P | ASP104 |
| P | SER106 |
| P | GLU134 |
| P | HOH339 |
| P | HOH397 |
| P | HOH1789 |
| P | HOH2376 |
| site_id | BC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TD3 P 311 |
| Chain | Residue |
| A | HOH2012 |
| P | ASP82 |
| P | HIS83 |
| P | HIS180 |
| P | GLY181 |
| P | LYS184 |
| P | HIS210 |
| P | GLY211 |
| P | ALA212 |
| P | SER213 |
| P | ASN253 |
| P | ASP255 |
| P | THR256 |
| P | ZN308 |
| P | HOH435 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN U 308 |
| Chain | Residue |
| U | HIS83 |
| U | HIS180 |
| U | HIS210 |
| U | TD3311 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA U 309 |
| Chain | Residue |
| U | GLN47 |
| U | HIS80 |
| U | ASP82 |
| U | MET102 |
| U | GLU132 |
| U | HIS210 |
| U | LYS251 |
| U | ASN253 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL U 310 |
| Chain | Residue |
| U | ASP104 |
| U | SER106 |
| U | GLU134 |
| U | HOH355 |
| U | HOH826 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TD3 U 311 |
| Chain | Residue |
| U | ASN23 |
| U | ASP82 |
| U | HIS83 |
| U | HIS180 |
| U | GLY181 |
| U | LYS184 |
| U | HIS210 |
| U | GLY211 |
| U | ALA212 |
| U | SER213 |
| U | ASN253 |
| U | ASP255 |
| U | THR256 |
| U | ZN308 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN Z 308 |
| Chain | Residue |
| Z | HIS83 |
| Z | HIS180 |
| Z | HIS210 |
| Z | TD3311 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA Z 309 |
| Chain | Residue |
| Z | GLN47 |
| Z | HIS80 |
| Z | ASP82 |
| Z | MET102 |
| Z | GLU132 |
| Z | HIS210 |
| Z | LYS251 |
| Z | ASN253 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL Z 310 |
| Chain | Residue |
| Z | ASP104 |
| Z | SER106 |
| Z | GLU134 |
| Z | HOH324 |
| Z | HOH1520 |
| Z | HOH1875 |
| site_id | CC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TD3 Z 311 |
| Chain | Residue |
| Z | ASP82 |
| Z | HIS83 |
| Z | HIS180 |
| Z | GLY181 |
| Z | LYS184 |
| Z | HIS210 |
| Z | GLY211 |
| Z | ALA212 |
| Z | SER213 |
| Z | ASN253 |
| Z | ASP255 |
| Z | THR256 |
| Z | ZN308 |
| Z | HOH1876 |
| Z | HOH1983 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN e 308 |
| Chain | Residue |
| e | HIS83 |
| e | HIS180 |
| e | HIS210 |
| e | TD3311 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA e 309 |
| Chain | Residue |
| e | HIS80 |
| e | ASP82 |
| e | MET102 |
| e | GLU132 |
| e | HIS210 |
| e | LYS251 |
| e | ASN253 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL e 310 |
| Chain | Residue |
| e | ASP104 |
| e | SER106 |
| e | GLU134 |
| e | HOH464 |
| site_id | DC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TD3 e 311 |
| Chain | Residue |
| e | ASN23 |
| e | ASP82 |
| e | HIS83 |
| e | HIS180 |
| e | GLY181 |
| e | LYS184 |
| e | HIS210 |
| e | GLY211 |
| e | ALA212 |
| e | SER213 |
| e | ASN253 |
| e | ASP255 |
| e | THR256 |
| e | ZN308 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN j 308 |
| Chain | Residue |
| j | HIS83 |
| j | HIS180 |
| j | HIS210 |
| j | TD3311 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NA j 309 |
| Chain | Residue |
| j | GLN47 |
| j | HIS80 |
| j | ASP82 |
| j | MET102 |
| j | GLU132 |
| j | HIS210 |
| j | LYS251 |
| j | ASN253 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL j 310 |
| Chain | Residue |
| j | ASP104 |
| j | SER106 |
| j | GLU134 |
| j | HOH943 |
| j | HOH1427 |
| site_id | DC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TD3 j 311 |
| Chain | Residue |
| j | ASP82 |
| j | HIS83 |
| j | HIS180 |
| j | GLY181 |
| j | LYS184 |
| j | HIS210 |
| j | GLY211 |
| j | ALA212 |
| j | SER213 |
| j | ASN253 |
| j | ASP255 |
| j | THR256 |
| j | ZN308 |
| j | HOH350 |
| j | HOH1682 |
Functional Information from PROSITE/UniProt
| site_id | PS00602 |
| Number of Residues | 13 |
| Details | ALDOLASE_CLASS_II_1 Fructose-bisphosphate aldolase class-II signature 1. Yph.IPVa.LHlDHG |
| Chain | Residue | Details |
| A | TYR72-GLY84 |
| site_id | PS00806 |
| Number of Residues | 12 |
| Details | ALDOLASE_CLASS_II_2 Fructose-bisphosphate aldolase class-II signature 2. VEaELGrlMGiE |
| Chain | Residue | Details |
| A | VAL131-GLU142 |
