3N8G
Structure of the (SR)Ca2+-ATPase Ca2-E1-CaAMPPCP form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0005215 | molecular_function | transporter activity |
A | 0005388 | molecular_function | P-type calcium transporter activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005524 | molecular_function | ATP binding |
A | 0006816 | biological_process | calcium ion transport |
A | 0006874 | biological_process | intracellular calcium ion homeostasis |
A | 0016020 | cellular_component | membrane |
A | 0016529 | cellular_component | sarcoplasmic reticulum |
A | 0016887 | molecular_function | ATP hydrolysis activity |
A | 0031448 | biological_process | positive regulation of fast-twitch skeletal muscle fiber contraction |
A | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0070588 | biological_process | calcium ion transmembrane transport |
A | 0106134 | biological_process | positive regulation of cardiac muscle cell contraction |
A | 1901896 | biological_process | positive regulation of ATPase-coupled calcium transmembrane transporter activity |
A | 1902082 | biological_process | positive regulation of calcium ion import into sarcoplasmic reticulum |
A | 1990036 | biological_process | calcium ion import into sarcoplasmic reticulum |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1002 |
Chain | Residue |
A | ASP351 |
A | THR353 |
A | ASP703 |
A | ACP1001 |
A | HOH1023 |
A | HOH1025 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 1003 |
Chain | Residue |
A | GLU309 |
A | ASN796 |
A | ASP800 |
A | VAL304 |
A | ALA305 |
A | ILE307 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 1004 |
Chain | Residue |
A | ASN768 |
A | GLU771 |
A | THR799 |
A | ASP800 |
A | GLU908 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 1006 |
Chain | Residue |
A | LEU711 |
A | LYS712 |
A | ALA714 |
A | GLU732 |
site_id | AC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE ACP A 1001 |
Chain | Residue |
A | ASP351 |
A | LYS352 |
A | THR353 |
A | GLU442 |
A | PHE487 |
A | ARG489 |
A | MET494 |
A | LYS515 |
A | GLY516 |
A | ALA517 |
A | ARG560 |
A | LEU562 |
A | THR625 |
A | GLY626 |
A | ASP627 |
A | ARG678 |
A | LYS684 |
A | ASN706 |
A | HOH997 |
A | CA1002 |
A | HOH1046 |
Functional Information from PROSITE/UniProt
site_id | PS00154 |
Number of Residues | 7 |
Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
Chain | Residue | Details |
A | ASP351-THR357 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 663 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | MET1-SER48 | |
A | ASN111-LEU253 | |
A | VAL314-MET757 | |
A | PHE809-LEU828 | |
A | GLU918-ASN930 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | LEU49-ALA69 |
site_id | SWS_FT_FI3 |
Number of Residues | 108 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | CYS70-VAL89 | |
A | ILE274-TYR295 | |
A | THR778-LEU787 | |
A | ALA852-MET897 | |
A | VAL950-LEU964 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | GLU90-ARG110 |
site_id | SWS_FT_FI5 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | ASP254-LEU273 |
site_id | SWS_FT_FI6 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | PHE296-ALA313 |
site_id | SWS_FT_FI7 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | LYS758-LEU777 |
site_id | SWS_FT_FI8 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | ILE788-GLY808 |
site_id | SWS_FT_FI9 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | ILE829-ALA851 |
site_id | SWS_FT_FI10 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | THR898-SER917 |
site_id | SWS_FT_FI11 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | ILE931-TYR949 |
site_id | SWS_FT_FI12 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:10864315 |
Chain | Residue | Details |
A | THR965-LYS985 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:18075584 |
Chain | Residue | Details |
A | ASP351 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | VAL304 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ALA305 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4NAB, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | ILE307 |
site_id | SWS_FT_FI17 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | GLU309 |
site_id | SWS_FT_FI18 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:1WPG, ECO:0007744|PDB:1XP5, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:2ZBE, ECO:0007744|PDB:2ZBF, ECO:0007744|PDB:2ZBG, ECO:0007744|PDB:3AR8, ECO:0007744|PDB:3AR9, ECO:0007744|PDB:3B9B, ECO:0007744|PDB:3B9R, ECO:0007744|PDB:3FGO, ECO:0007744|PDB:3FPB, ECO:0007744|PDB:3N5K, ECO:0007744|PDB:4BEW, ECO:0007744|PDB:5A3Q, ECO:0007744|PDB:5A3S |
Chain | Residue | Details |
A | ASP351 | |
A | THR353 | |
A | ASP703 |
site_id | SWS_FT_FI19 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:2BY4, ECO:0007744|PDB:2C88, ECO:0007744|PDB:2DQS, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3AR3, ECO:0007744|PDB:4UU1, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | GLU442 |
site_id | SWS_FT_FI20 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:1WPG, ECO:0007744|PDB:2DQS, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3B9R, ECO:0007744|PDB:3FGO, ECO:0007744|PDB:3FPB, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4BEW, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ARG489 |
site_id | SWS_FT_FI21 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:2BY4, ECO:0007744|PDB:2C8K, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4UU1, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | LYS515 |
site_id | SWS_FT_FI22 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2BY4, ECO:0007744|PDB:2C88, ECO:0007744|PDB:2C8K, ECO:0007744|PDB:2DQS, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3B9R, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4H1W, ECO:0007744|PDB:4UU1, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | ARG560 |
site_id | SWS_FT_FI23 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | THR625 |
site_id | SWS_FT_FI24 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4UU1, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | GLY626 |
site_id | SWS_FT_FI25 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0007744|PDB:1T5T |
Chain | Residue | Details |
A | ASP627 |
site_id | SWS_FT_FI26 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3FGO, ECO:0007744|PDB:3FPB, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4BEW, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ARG678 |
site_id | SWS_FT_FI27 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | LYS684 |
site_id | SWS_FT_FI28 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | ASN706 |
site_id | SWS_FT_FI29 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4NAB, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ASN768 | |
A | THR799 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | GLU771 |
site_id | SWS_FT_FI31 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ASN796 |
site_id | SWS_FT_FI32 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5T, ECO:0007744|PDB:1VFP, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:2ZBD, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:3N8G, ECO:0007744|PDB:4NAB, ECO:0007744|PDB:4XOU, ECO:0007744|PDB:5XA7, ECO:0007744|PDB:5XA8 |
Chain | Residue | Details |
A | ASP800 |
site_id | SWS_FT_FI33 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10864315, ECO:0000269|PubMed:15192230, ECO:0000269|PubMed:15229613, ECO:0000269|PubMed:26175901, ECO:0007744|PDB:1SU4, ECO:0007744|PDB:1T5S, ECO:0007744|PDB:2C9M, ECO:0007744|PDB:3AR2, ECO:0007744|PDB:3BA6, ECO:0007744|PDB:4NAB, ECO:0007744|PDB:4XOU |
Chain | Residue | Details |
A | GLU908 |
site_id | SWS_FT_FI34 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q64578 |
Chain | Residue | Details |
A | THR441 | |
A | THR569 |
site_id | SWS_FT_FI35 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q64578 |
Chain | Residue | Details |
A | SER581 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 849 |
Chain | Residue | Details |
A | ASP351 | covalent catalysis |
A | ASP703 | metal ligand |
A | ASP707 | metal ligand |