3N75

X-ray Crystal Structure of the Escherichia coli Inducible Lysine Decarboxylase LdcI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006554	biological_process	lysine catabolic process
A	0008923	molecular_function	lysine decarboxylase activity
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0042802	molecular_function	identical protein binding
A	0097216	molecular_function	guanosine tetraphosphate binding
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0006554	biological_process	lysine catabolic process
B	0008923	molecular_function	lysine decarboxylase activity
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0042802	molecular_function	identical protein binding
B	0097216	molecular_function	guanosine tetraphosphate binding
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0006554	biological_process	lysine catabolic process
C	0008923	molecular_function	lysine decarboxylase activity
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0042802	molecular_function	identical protein binding
C	0097216	molecular_function	guanosine tetraphosphate binding
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0006554	biological_process	lysine catabolic process
D	0008923	molecular_function	lysine decarboxylase activity
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0042802	molecular_function	identical protein binding
D	0097216	molecular_function	guanosine tetraphosphate binding
E	0003824	molecular_function	catalytic activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0006554	biological_process	lysine catabolic process
E	0008923	molecular_function	lysine decarboxylase activity
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0042802	molecular_function	identical protein binding
E	0097216	molecular_function	guanosine tetraphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE G4P A 716

Chain	Residue
A	ARG97
D	ARG558
D	LEU564
D	ARG565
D	ASN568
D	ARG585
D	HOH2335
A	ARG206
A	LYS417
A	GLY418
A	HOH2524
A	HOH3224
A	HOH3228
A	HOH3230
A	HOH3237

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P6G A 717

Chain	Residue
A	HIS9
A	GLU16
A	ARG20
A	TYR35
A	HOH1358
A	HOH2141

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 718

Chain	Residue
A	HIS282
A	ASP323

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE G4P B 716

Chain	Residue
B	ARG97
B	ARG206
B	LYS417
B	GLY418
B	HOH3225
B	HOH3231
E	ARG558
E	LEU564
E	ARG565
E	ASN568
E	ARG585
E	HOH3235

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P6G B 717

Chain	Residue
B	HIS9
B	ARG20
B	TYR35
B	HOH1872
B	HOH2157
B	HOH2958

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 718

Chain	Residue
B	HIS282
B	TRP297

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G4P C 716

Chain	Residue
A	ARG558
A	LEU564
A	ARG565
A	ASN568
A	ARG585
C	ARG97
C	ARG206
C	LYS417
C	GLY418
C	HOH1862
C	HOH2111
C	HOH2130
C	HOH2198
C	HOH3262

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P6G C 717

Chain	Residue
C	ASN8
C	HIS9
C	GLU16
C	ARG20
C	TYR35
C	HOH1874
C	HOH2138
C	HOH3120

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL C 718

Chain	Residue
C	HIS282

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G4P D 716

Chain	Residue
B	ARG558
B	LEU564
B	ARG565
B	ASN568
B	ARG585
B	HOH3232
D	ARG97
D	ARG206
D	LYS417
D	GLY418
D	HOH1859
D	HOH2183
D	HOH3236
D	HOH3274

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P6G D 717

Chain	Residue
D	ASN8
D	HIS9
D	GLU16
D	ARG20
D	HOH1879

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL D 718

Chain	Residue
D	HIS282
D	TRP297

---

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE G4P E 716

Chain	Residue
E	HOH3223
E	HOH3227
E	HOH3229
E	HOH3233
E	HOH3234
E	HOH3265
E	HOH3269
E	HOH3271
E	HOH3272
C	ARG558
C	LEU562
C	LEU564
C	ARG565
C	ASN568
C	ARG585
E	ARG97
E	ARG206
E	LYS417
E	GLY418
E	HOH1832
E	HOH2573

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P6G E 717

Chain	Residue
E	HIS9
E	GLU16
E	ARG20
E	TYR35
E	HOH2145

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL E 718

Chain	Residue
E	HIS282
E	TRP297
E	ASP323

---

Functional Information from PROSITE/UniProt

site_id	PS00703
Number of Residues	15
Details	OKR_DC_1 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. TqStHKllAAfSQAS

Chain	Residue	Details
A	THR362-SER376

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"}

Chain

Residue

Details

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