3N2L

2.1 Angstrom resolution crystal structure of an Orotate Phosphoribosyltransferase (pyrE) from Vibrio cholerae O1 biovar eltor str. N16961

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004588	molecular_function	orotate phosphoribosyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004588	molecular_function	orotate phosphoribosyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0004588	molecular_function	orotate phosphoribosyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016757	molecular_function	glycosyltransferase activity
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0004588	molecular_function	orotate phosphoribosyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016757	molecular_function	glycosyltransferase activity
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 215

Chain	Residue
A	ARG100
B	TYR73
B	LYS74

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 215

Chain	Residue
G	ARG100
H	TYR73
H	LYS74

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 216

Chain	Residue
H	GLN158
H	LEU185
H	THR186

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA

Chain	Residue	Details
A	VAL121-ALA133

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site_id	PS00136
Number of Residues	11
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. AALVDSGIef.D

Chain	Residue	Details
A	ALA56-ASP66

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_01208","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01208","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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