Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3N2L

2.1 Angstrom resolution crystal structure of an Orotate Phosphoribosyltransferase (pyrE) from Vibrio cholerae O1 biovar eltor str. N16961

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072528	biological_process	pyrimidine-containing compound biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0072528	biological_process	pyrimidine-containing compound biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0072528	biological_process	pyrimidine-containing compound biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004588	molecular_function	orotate phosphoribosyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0016757	molecular_function	glycosyltransferase activity
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
E	0055086	biological_process	nucleobase-containing small molecule metabolic process
E	0072528	biological_process	pyrimidine-containing compound biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004588	molecular_function	orotate phosphoribosyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0016757	molecular_function	glycosyltransferase activity
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
F	0055086	biological_process	nucleobase-containing small molecule metabolic process
F	0072528	biological_process	pyrimidine-containing compound biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0004588	molecular_function	orotate phosphoribosyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0016757	molecular_function	glycosyltransferase activity
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
G	0055086	biological_process	nucleobase-containing small molecule metabolic process
G	0072528	biological_process	pyrimidine-containing compound biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0004588	molecular_function	orotate phosphoribosyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0016757	molecular_function	glycosyltransferase activity
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
H	0055086	biological_process	nucleobase-containing small molecule metabolic process
H	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 215

Chain	Residue
A	ARG100
B	TYR73
B	LYS74

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 215

Chain	Residue
G	ARG100
H	TYR73
H	LYS74

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H 216

Chain	Residue
H	GLN158
H	LEU185
H	THR186

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA

Chain	Residue	Details
A	VAL121-ALA133

site_id	PS00136
Number of Residues	11
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. AALVDSGIef.D

Chain	Residue	Details
A	ALA56-ASP66

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	LYS27
C	TYR73
C	LYS101
C	ASP125
D	LYS27
D	TYR73
D	LYS101
D	ASP125
E	LYS27
E	TYR73
E	LYS101
A	TYR73
E	ASP125
F	LYS27
F	TYR73
F	LYS101
F	ASP125
G	LYS27
G	TYR73
G	LYS101
G	ASP125
H	LYS27
A	LYS101
H	TYR73
H	LYS101
H	ASP125
A	ASP125
B	LYS27
B	TYR73
B	LYS101
B	ASP125
C	LYS27

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01208

Chain	Residue	Details
A	PHE35
B	HIS106
B	THR129
B	ARG157
C	PHE35
C	ARG100
C	LYS104
C	HIS106
C	THR129
C	ARG157
D	PHE35
A	ARG100
D	ARG100
D	LYS104
D	HIS106
D	THR129
D	ARG157
E	PHE35
E	ARG100
E	LYS104
E	HIS106
E	THR129
A	LYS104
E	ARG157
F	PHE35
F	ARG100
F	LYS104
F	HIS106
F	THR129
F	ARG157
G	PHE35
G	ARG100
G	LYS104
A	HIS106
G	HIS106
G	THR129
G	ARG157
H	PHE35
H	ARG100
H	LYS104
H	HIS106
H	THR129
H	ARG157
A	THR129
A	ARG157
B	PHE35
B	ARG100
B	LYS104

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)