3N2I
2.25 Angstrom resolution crystal structure of a thymidylate kinase (tmk) from Vibrio cholerae O1 biovar eltor str. N16961 in complex with thymidine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006227 | biological_process | dUDP biosynthetic process |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006227 | biological_process | dUDP biosynthetic process |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 213 |
Chain | Residue |
A | GLY13 |
A | ALA14 |
A | GLY15 |
A | LYS16 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THM A 214 |
Chain | Residue |
A | SER102 |
A | SER103 |
A | TYR106 |
A | GLN107 |
A | ILE157 |
A | HOH249 |
A | GLU12 |
A | GLU40 |
A | PRO41 |
A | ARG51 |
A | ARG76 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 213 |
Chain | Residue |
B | GLY13 |
B | ALA14 |
B | GLY15 |
B | LYS16 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE THM B 214 |
Chain | Residue |
B | GLU40 |
B | PRO41 |
B | ARG51 |
B | VAL72 |
B | ARG76 |
B | ARG98 |
B | SER102 |
B | SER103 |
B | TYR106 |
B | GLN107 |
B | ASP155 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. VGDRHdmSSqAYQ |
Chain | Residue | Details |
A | VAL95-GLN107 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255 |
Chain | Residue | Details |
A | GLY10 | |
B | GLY10 |