3MZH
Crystal structure of cAMP receptor protein from mycobacterium tuberculosis in complex with cAMP and its DNA binding element
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0030552 | molecular_function | cAMP binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CMP A 623 |
| Chain | Residue |
| A | PHE38 |
| A | SER91 |
| A | ARG130 |
| A | THR134 |
| B | ARG132 |
| B | ASN135 |
| A | LEU69 |
| A | PHE78 |
| A | GLY79 |
| A | GLU80 |
| A | LEU81 |
| A | SER82 |
| A | ARG89 |
| A | THR90 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CMP B 621 |
| Chain | Residue |
| A | ILE142 |
| B | ASN67 |
| B | LEU68 |
| B | LEU69 |
| B | ASN137 |
| B | ASP140 |
| B | LEU141 |
| B | ARG149 |
| B | LYS152 |
| B | GLN153 |
| B | GLN156 |
| B | GLN182 |
| B | LEU183 |
| B | VAL184 |
| B | GLY185 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CMP B 622 |
| Chain | Residue |
| A | LEU131 |
| A | ASN135 |
| B | PHE38 |
| B | ILE57 |
| B | THR70 |
| B | PHE78 |
| B | GLY79 |
| B | GLU80 |
| B | LEU81 |
| B | SER82 |
| B | ARG89 |
| B | SER91 |
| B | ARG130 |
| B | ARG133 |
| B | THR134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387 |
| Chain | Residue | Details |
| A | GLN177-ALA196 | |
| B | GLN177-ALA196 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0ACJ8 |
| Chain | Residue | Details |
| A | GLY64 | |
| A | ILE142 | |
| A | GLU178 | |
| B | GLY64 | |
| B | ILE142 | |
| B | GLU178 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|Ref.9 |
| Chain | Residue | Details |
| A | GLY79 | |
| A | ARG89 | |
| A | THR134 | |
| B | GLY79 | |
| B | ARG89 | |
| B | THR134 |
