3MZG
Crystal structure of a human prolactin receptor antagonist in complex with the extracellular domain of the human prolactin receptor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001937 | biological_process | negative regulation of endothelial cell proliferation |
A | 0005148 | molecular_function | prolactin receptor binding |
A | 0005179 | molecular_function | hormone activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0007166 | biological_process | cell surface receptor signaling pathway |
A | 0007565 | biological_process | female pregnancy |
A | 0007595 | biological_process | lactation |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0016525 | biological_process | negative regulation of angiogenesis |
A | 0030879 | biological_process | mammary gland development |
A | 0031667 | biological_process | response to nutrient levels |
A | 0031904 | cellular_component | endosome lumen |
A | 0038161 | biological_process | prolactin signaling pathway |
A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
A | 1902895 | biological_process | positive regulation of miRNA transcription |
A | 1903489 | biological_process | positive regulation of lactation |
B | 0004896 | molecular_function | cytokine receptor activity |
B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B 211 |
Chain | Residue |
A | ASP68 |
A | HOH265 |
B | LYS66 |
B | THR69 |
B | HOH321 |
B | HOH364 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B 212 |
Chain | Residue |
B | TRP191 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B 213 |
Chain | Residue |
B | ASN60 |
B | SER61 |
B | HOH345 |
B | HOH365 |
B | TRP24 |
B | TYR54 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 214 |
Chain | Residue |
B | PRO15 |
B | THR19 |
B | PHE20 |
B | THR21 |
B | HIS63 |
Functional Information from PROSITE/UniProt
site_id | PS00266 |
Number of Residues | 34 |
Details | SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. ChTssLaTPedkeqAqqmnqkdFlslivsIlrSW |
Chain | Residue | Details |
A | CYS58-TRP91 |
site_id | PS00338 |
Number of Residues | 18 |
Details | SOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CLRrDShKIDnYlkLlkC |
Chain | Residue | Details |
A | CYS174-CYS191 |
site_id | PS01352 |
Number of Residues | 78 |
Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. LwIkWspptlidlktgwftllYEIrlkpekaaeweihfagqqtefkils..LhpgqkylvqvRcKpdhgy....WsaWspatfI |
Chain | Residue | Details |
B | LEU123-ILE200 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 209 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
B | MET1-ASP210 | |
A | SER34 | |
A | SER90 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
B | ASP187 | |
B | HIS188 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
B | ASN35 | |
B | ASN80 | |
B | ASN209 |