3MZ9
X-ray structure of NikA in complex with HBED
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FE A 503 |
| Chain | Residue |
| A | BHN504 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BHN A 504 |
| Chain | Residue |
| A | FE503 |
| A | HOH597 |
| A | HOH691 |
| A | HOH867 |
| A | HOH901 |
| A | HOH927 |
| A | TYR22 |
| A | THR23 |
| A | MET27 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | HIS416 |
| A | THR490 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DTD A 505 |
| Chain | Residue |
| A | TRP10 |
| A | PRO11 |
| A | ARG205 |
| A | GLY219 |
| A | ASN220 |
| A | GLY222 |
| A | HOH774 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 506 |
| Chain | Residue |
| A | LYS335 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 507 |
| Chain | Residue |
| A | ASP387 |
| A | ARG389 |
| A | HOH551 |
| A | HOH709 |
| B | ASP453 |
| B | THR456 |
| B | HOH562 |
| B | HOH596 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 508 |
| Chain | Residue |
| A | VAL273 |
| A | ASN274 |
| A | LYS275 |
| A | GLN309 |
| A | TYR310 |
| A | HOH721 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 509 |
| Chain | Residue |
| A | ARG457 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 510 |
| Chain | Residue |
| A | GLN241 |
| A | ASN482 |
| A | ILE483 |
| A | TYR485 |
| A | HOH646 |
| A | HOH780 |
| B | PRO299 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 511 |
| Chain | Residue |
| A | ASN270 |
| A | ASP291 |
| A | HIS459 |
| A | ALA462 |
| A | TYR464 |
| A | HOH539 |
| A | HOH577 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 512 |
| Chain | Residue |
| A | LYS52 |
| A | ARG68 |
| A | ASP69 |
| A | ASP70 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 513 |
| Chain | Residue |
| A | ASN261 |
| A | GLU262 |
| A | LEU263 |
| A | GOL524 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 514 |
| Chain | Residue |
| A | ASN235 |
| A | LYS428 |
| A | PRO429 |
| A | HOH566 |
| A | HOH649 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 515 |
| Chain | Residue |
| A | ASN482 |
| A | GLN496 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 516 |
| Chain | Residue |
| A | GLN385 |
| A | PHE394 |
| A | HIS395 |
| A | ARG396 |
| A | HOH692 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 517 |
| Chain | Residue |
| A | ARG384 |
| A | HOH622 |
| B | LEU430 |
| B | ARG457 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 518 |
| Chain | Residue |
| A | LEU167 |
| A | GLN168 |
| A | HOH919 |
| B | THR211 |
| B | ASP213 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 519 |
| Chain | Residue |
| A | LYS148 |
| A | ASN149 |
| A | LYS157 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 520 |
| Chain | Residue |
| A | SER243 |
| A | ILE246 |
| A | TYR485 |
| A | ALA486 |
| A | ALA489 |
| A | HOH638 |
| A | HOH786 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 521 |
| Chain | Residue |
| A | LEU92 |
| A | VAL108 |
| A | ASN281 |
| A | HOH934 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 522 |
| Chain | Residue |
| A | PHE79 |
| A | ASP80 |
| A | LYS115 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 523 |
| Chain | Residue |
| A | ARG89 |
| A | PRO144 |
| A | PHE147 |
| A | HIS150 |
| A | HOH549 |
| A | GLU86 |
| site_id | CC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 524 |
| Chain | Residue |
| A | THR255 |
| A | ASN261 |
| A | ARG266 |
| A | GLY424 |
| A | LEU425 |
| A | ALA426 |
| A | ACT513 |
| A | HOH677 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 525 |
| Chain | Residue |
| A | GLN26 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 526 |
| Chain | Residue |
| A | SER233 |
| B | ASN302 |
| B | HOH673 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE FE B 503 |
| Chain | Residue |
| B | BHN504 |
| site_id | CC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE BHN B 504 |
| Chain | Residue |
| B | TYR22 |
| B | THR23 |
| B | MET27 |
| B | TRP100 |
| B | ARG137 |
| B | TRP398 |
| B | THR490 |
| B | FE503 |
| B | HOH538 |
| B | HOH659 |
| B | HOH924 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DTD B 505 |
| Chain | Residue |
| B | TRP10 |
| B | PRO11 |
| B | ARG205 |
| B | GLY219 |
| B | ASN220 |
| B | HOH527 |
| site_id | DC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 506 |
| Chain | Residue |
| B | GLU267 |
| B | ASN270 |
| B | TYR271 |
| B | SER308 |
| B | HIS459 |
| B | ASP460 |
| B | ALA462 |
| B | HOH594 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B 507 |
| Chain | Residue |
| A | ASN302 |
| A | GLY304 |
| B | PHE229 |
| B | ALA230 |
| B | SER233 |
| B | THR286 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 508 |
| Chain | Residue |
| B | THR203 |
| B | PRO225 |
| B | ASP227 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 509 |
| Chain | Residue |
| B | ILE246 |
| B | TYR485 |
| B | ALA486 |
| B | HOH640 |
| B | HOH682 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 510 |
| Chain | Residue |
| B | TRP10 |
| B | MET27 |
| B | PHE28 |
| B | HOH642 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
