3MXI

TREX1 3' Exonuclease D18N Familial Chilblain Lupus Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008408	molecular_function	3'-5' exonuclease activity
B	0003676	molecular_function	nucleic acid binding
B	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 243

Chain	Residue
B	ASN18
B	GLU20
B	HIS195
B	ASP200
C	DG4

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 243

Chain	Residue
D	DG4
A	ASN18
A	GLU20
A	HIS195
A	ASP200

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 5

Chain	Residue
B	ASN18
B	HOH250
C	DC3
C	DG4
C	HOH74

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 5

Chain	Residue
A	ASN18
A	HOH253
A	HOH254
D	DC3
D	DG4
D	HOH23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17293595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22071149","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NSU2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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