3MX8
Crystal structure of ribonuclease A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 253 |
Chain | Residue |
A | HIS12 |
A | LYS41 |
A | VAL43 |
A | ASN44 |
A | THR45 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 254 |
Chain | Residue |
A | HOH272 |
A | HOH292 |
A | HOH295 |
A | HOH296 |
A | HOH383 |
A | LYS1 |
A | THR3 |
A | ALA4 |
A | ASN190 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 255 |
Chain | Residue |
A | GLN139 |
A | HIS140 |
A | LYS169 |
A | HIS247 |
A | PHE248 |
A | HOH265 |
A | HOH342 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 256 |
Chain | Residue |
A | GLN11 |
A | HIS12 |
A | VAL118 |
A | HIS119 |
A | PHE120 |
A | HOH287 |
A | HOH416 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 257 |
Chain | Residue |
A | THR131 |
A | ALA132 |
A | HOH280 |
A | HOH446 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 258 |
Chain | Residue |
A | HIS140 |
A | ASN172 |
A | THR173 |
A | HOH342 |
A | HOH365 |
Functional Information from PROSITE/UniProt
site_id | PS00127 |
Number of Residues | 7 |
Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF |
Chain | Residue | Details |
A | CYS40-PHE46 | |
A | CYS168-PHE174 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS140 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | HIS247 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS135 | |
A | ARG138 | |
A | LYS169 | |
A | LYS194 | |
A | ARG213 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 |
Chain | Residue | Details |
A | LYS129 | |
A | LYS135 | |
A | LYS165 | |
A | LYS169 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 |
Chain | Residue | Details |
A | ASN162 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 164 |
Chain | Residue | Details |
A | HIS140 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | LYS169 | electrostatic stabiliser, hydrogen bond donor |
A | HIS247 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | PHE248 | electrostatic stabiliser, hydrogen bond donor |
A | ASP249 | electrostatic stabiliser, hydrogen bond acceptor |