3MWT

Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0019013	cellular_component	viral nucleocapsid
A	0019028	cellular_component	viral capsid
A	0019029	cellular_component	helical viral capsid
A	0030430	cellular_component	host cell cytoplasm
A	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A	0039689	biological_process	negative stranded viral RNA replication
A	0039696	biological_process	RNA-templated viral transcription
A	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
A	0042802	molecular_function	identical protein binding
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0019013	cellular_component	viral nucleocapsid
B	0019028	cellular_component	viral capsid
B	0019029	cellular_component	helical viral capsid
B	0030430	cellular_component	host cell cytoplasm
B	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
B	0039689	biological_process	negative stranded viral RNA replication
B	0039696	biological_process	RNA-templated viral transcription
B	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
B	0042802	molecular_function	identical protein binding
B	0044423	cellular_component	virion component
B	0046872	molecular_function	metal ion binding
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0008408	molecular_function	3'-5' exonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0019013	cellular_component	viral nucleocapsid
C	0019028	cellular_component	viral capsid
C	0019029	cellular_component	helical viral capsid
C	0030430	cellular_component	host cell cytoplasm
C	0039548	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
C	0039689	biological_process	negative stranded viral RNA replication
C	0039696	biological_process	RNA-templated viral transcription
C	0039724	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
C	0042802	molecular_function	identical protein binding
C	0044423	cellular_component	virion component
C	0046872	molecular_function	metal ion binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 680

Chain	Residue
A	ASP389
A	GLU391
A	ASP533

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 690

Chain	Residue
A	GLU399
A	HIS412
A	CYS506
A	HIS509
A	CYS529

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN B 680

Chain	Residue
B	GLU391
B	ASP533
B	ASP389

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 690

Chain	Residue
B	GLU399
B	HIS412
B	CYS506
B	HIS509
B	CYS529

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN C 680

Chain	Residue
C	ASP389
C	GLU391
C	ASP533

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 690

Chain	Residue
C	GLU399
C	CYS506
C	HIS509
C	CYS529

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835

Chain	Residue	Details
A	ASP389
A	GLU391
A	ASP533
B	ASP389
B	GLU391
B	ASP533
C	ASP389
C	GLU391
C	ASP533

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117, ECO:0000269|PubMed:21262835, ECO:0000269|PubMed:22937163, ECO:0000269|PubMed:23615902

Chain	Residue	Details
A	GLU399
C	CYS506
C	HIS509
C	CYS529
A	CYS506
A	HIS509
A	CYS529
B	GLU399
B	CYS506
B	HIS509
B	CYS529
C	GLU399

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Important for exonuclease activity => ECO:0000255|HAMAP-Rule:MF_04085, ECO:0000269|PubMed:21085117

Chain	Residue	Details
A	ASP466
B	ASP466
C	ASP466

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