3MWE

Truncated Human ATP-Citrate Lyase with Tartrate Bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0003824	molecular_function	catalytic activity
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 426

Chain	Residue
A	ASP257
A	SER260
A	ALA262
A	HOH624

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TLA A 427

Chain	Residue
A	THR348
A	ARG379
A	HOH531
A	HOH1362
A	GLY309
A	ALA310
A	ALA345
A	ASN346
A	PHE347

---

Functional Information from PROSITE/UniProt

site_id	PS00399
Number of Residues	17
Details	SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GtcAtmfssevQFGHAG

Chain	Residue	Details
B	GLY746-GLY762

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site_id	PS01216
Number of Residues	30
Details	SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGGMSnElnniisrttdGvyegVAIGGD

Chain	Residue	Details
B	SER661-ASP690

---

site_id	PS01217
Number of Residues	25
Details	SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GrIwtMvAGGGASvvysDtIcdl.GG

Chain	Residue	Details
A	GLY273-GLY297

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000305|PubMed:1371749

Chain	Residue	Details
B	HIS760
A	ARG66
A	GLY67
A	PRO109
A	VAL111
A	GLU118
A	ASP216

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
B	LEU779
A	SER260
A	ALA262

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781

Chain	Residue	Details
B	LYS540
A	ASN346
A	THR348
A	TYR364
A	ARG379

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781, ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS546
B	LYS554

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
B	THR639

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
B	SER663

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195

Chain	Residue	Details
B	TYR682

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site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27664236, ECO:0000305|PubMed:23932781

Chain	Residue	Details
B	LYS540
B	LYS546
B	LYS554

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