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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3MVT

Crystal structure of apo mADA at 2.2A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001701biological_processin utero embryonic development
A0001821biological_processhistamine secretion
A0001829biological_processtrophectodermal cell differentiation
A0001883molecular_functionpurine nucleoside binding
A0001889biological_processliver development
A0001890biological_processplacenta development
A0002314biological_processgerminal center B cell differentiation
A0002636biological_processpositive regulation of germinal center formation
A0002686biological_processnegative regulation of leukocyte migration
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004000molecular_functionadenosine deaminase activity
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006196biological_processAMP catabolic process
A0007155biological_processcell adhesion
A0008270molecular_functionzinc ion binding
A0009117biological_processnucleotide metabolic process
A0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010460biological_processpositive regulation of heart rate
A0014074biological_processresponse to purine-containing compound
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019239molecular_functiondeaminase activity
A0030324biological_processlung development
A0030890biological_processpositive regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032261biological_processpurine nucleotide salvage
A0032264biological_processIMP salvage
A0032839cellular_componentdendrite cytoplasm
A0033081biological_processregulation of T cell differentiation in thymus
A0033089biological_processpositive regulation of T cell differentiation in thymus
A0033197biological_processresponse to vitamin E
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0042110biological_processT cell activation
A0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043103biological_processhypoxanthine salvage
A0045187biological_processregulation of circadian sleep/wake cycle, sleep
A0045580biological_processregulation of T cell differentiation
A0045582biological_processpositive regulation of T cell differentiation
A0045987biological_processpositive regulation of smooth muscle contraction
A0046059biological_processdAMP catabolic process
A0046061biological_processdATP catabolic process
A0046085biological_processadenosine metabolic process
A0046101biological_processhypoxanthine biosynthetic process
A0046103biological_processinosine biosynthetic process
A0046111biological_processxanthine biosynthetic process
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046872molecular_functionmetal ion binding
A0046936molecular_function2'-deoxyadenosine deaminase activity
A0048286biological_processlung alveolus development
A0048541biological_processPeyer's patch development
A0048566biological_processembryonic digestive tract development
A0050728biological_processnegative regulation of inflammatory response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0050870biological_processpositive regulation of T cell activation
A0060169biological_processnegative regulation of adenosine receptor signaling pathway
A0060205cellular_componentcytoplasmic vesicle lumen
A0060407biological_processnegative regulation of penile erection
A0070161cellular_componentanchoring junction
A0070244biological_processnegative regulation of thymocyte apoptotic process
A0070256biological_processnegative regulation of mucus secretion
A0140928biological_processinhibition of non-skeletal tissue mineralization
C0001666biological_processresponse to hypoxia
C0001701biological_processin utero embryonic development
C0001821biological_processhistamine secretion
C0001829biological_processtrophectodermal cell differentiation
C0001883molecular_functionpurine nucleoside binding
C0001889biological_processliver development
C0001890biological_processplacenta development
C0002314biological_processgerminal center B cell differentiation
C0002636biological_processpositive regulation of germinal center formation
C0002686biological_processnegative regulation of leukocyte migration
C0002906biological_processnegative regulation of mature B cell apoptotic process
C0004000molecular_functionadenosine deaminase activity
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006154biological_processadenosine catabolic process
C0006157biological_processdeoxyadenosine catabolic process
C0006196biological_processAMP catabolic process
C0007155biological_processcell adhesion
C0008270molecular_functionzinc ion binding
C0009117biological_processnucleotide metabolic process
C0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010460biological_processpositive regulation of heart rate
C0014074biological_processresponse to purine-containing compound
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019239molecular_functiondeaminase activity
C0030324biological_processlung development
C0030890biological_processpositive regulation of B cell proliferation
C0031410cellular_componentcytoplasmic vesicle
C0032261biological_processpurine nucleotide salvage
C0032264biological_processIMP salvage
C0032839cellular_componentdendrite cytoplasm
C0033081biological_processregulation of T cell differentiation in thymus
C0033089biological_processpositive regulation of T cell differentiation in thymus
C0033197biological_processresponse to vitamin E
C0033632biological_processregulation of cell-cell adhesion mediated by integrin
C0042110biological_processT cell activation
C0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
C0043025cellular_componentneuronal cell body
C0043066biological_processnegative regulation of apoptotic process
C0043103biological_processhypoxanthine salvage
C0045187biological_processregulation of circadian sleep/wake cycle, sleep
C0045580biological_processregulation of T cell differentiation
C0045582biological_processpositive regulation of T cell differentiation
C0045987biological_processpositive regulation of smooth muscle contraction
C0046059biological_processdAMP catabolic process
C0046061biological_processdATP catabolic process
C0046085biological_processadenosine metabolic process
C0046101biological_processhypoxanthine biosynthetic process
C0046103biological_processinosine biosynthetic process
C0046111biological_processxanthine biosynthetic process
C0046638biological_processpositive regulation of alpha-beta T cell differentiation
C0046872molecular_functionmetal ion binding
C0046936molecular_function2'-deoxyadenosine deaminase activity
C0048286biological_processlung alveolus development
C0048541biological_processPeyer's patch development
C0048566biological_processembryonic digestive tract development
C0050728biological_processnegative regulation of inflammatory response
C0050850biological_processpositive regulation of calcium-mediated signaling
C0050862biological_processpositive regulation of T cell receptor signaling pathway
C0050870biological_processpositive regulation of T cell activation
C0060169biological_processnegative regulation of adenosine receptor signaling pathway
C0060205cellular_componentcytoplasmic vesicle lumen
C0060407biological_processnegative regulation of penile erection
C0070161cellular_componentanchoring junction
C0070244biological_processnegative regulation of thymocyte apoptotic process
C0070256biological_processnegative regulation of mucus secretion
C0140928biological_processinhibition of non-skeletal tissue mineralization
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 902
ChainResidue
AHIS17
AASP19
ATYR102
ASER103
ALEU106
site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL C 902
ChainResidue
CLEU106
CHOH383
CHIS17
CASP19
CTYR102
CSER103
site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL C 401
ChainResidue
CHIS15
CHIS214
Functional Information from PROSITE/UniProt
site_idPS00485
Number of Residues7
DetailsA_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP
ChainResidueDetails
ASER291-PRO297
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"8634299","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ADA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"1925539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ADA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8672487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Important for interaction with adenosine receptors and increasing their affinity for agonists","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"8942668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9622483","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P00813","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 376
ChainResidueDetails
AHIS15metal ligand
AHIS17metal ligand
AHIS214metal ligand
AGLU217proton shuttle (general acid/base)
AHIS238proton shuttle (general acid/base)
AASP295metal ligand, steric role
site_idMCSA2
Number of Residues6
DetailsM-CSA 376
ChainResidueDetails

247536

PDB entries from 2026-01-14

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