Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MVT

Crystal structure of apo mADA at 2.2A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000255	biological_process	allantoin metabolic process
A	0001666	biological_process	response to hypoxia
A	0001701	biological_process	in utero embryonic development
A	0001829	biological_process	trophectodermal cell differentiation
A	0001889	biological_process	liver development
A	0001890	biological_process	placenta development
A	0002314	biological_process	germinal center B cell differentiation
A	0002467	biological_process	germinal center formation
A	0002636	biological_process	positive regulation of germinal center formation
A	0002686	biological_process	negative regulation of leukocyte migration
A	0002901	biological_process	mature B cell apoptotic process
A	0002906	biological_process	negative regulation of mature B cell apoptotic process
A	0004000	molecular_function	adenosine deaminase activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006154	biological_process	adenosine catabolic process
A	0006157	biological_process	deoxyadenosine catabolic process
A	0006196	biological_process	AMP catabolic process
A	0006915	biological_process	apoptotic process
A	0006939	biological_process	smooth muscle contraction
A	0007155	biological_process	cell adhesion
A	0008270	molecular_function	zinc ion binding
A	0009117	biological_process	nucleotide metabolic process
A	0009168	biological_process	purine ribonucleoside monophosphate biosynthetic process
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010460	biological_process	positive regulation of heart rate
A	0014074	biological_process	response to purine-containing compound
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019239	molecular_function	deaminase activity
A	0019722	biological_process	calcium-mediated signaling
A	0030217	biological_process	T cell differentiation
A	0030324	biological_process	lung development
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031410	cellular_component	cytoplasmic vesicle
A	0032261	biological_process	purine nucleotide salvage
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0033077	biological_process	T cell differentiation in thymus
A	0033089	biological_process	positive regulation of T cell differentiation in thymus
A	0033632	biological_process	regulation of cell-cell adhesion mediated by integrin
A	0042100	biological_process	B cell proliferation
A	0042110	biological_process	T cell activation
A	0043066	biological_process	negative regulation of apoptotic process
A	0043084	biological_process	penile erection
A	0043605	biological_process	amide catabolic process
A	0044209	biological_process	AMP salvage
A	0045580	biological_process	regulation of T cell differentiation
A	0045582	biological_process	positive regulation of T cell differentiation
A	0045987	biological_process	positive regulation of smooth muscle contraction
A	0046059	biological_process	dAMP catabolic process
A	0046061	biological_process	dATP catabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046101	biological_process	hypoxanthine biosynthetic process
A	0046103	biological_process	inosine biosynthetic process
A	0046111	biological_process	xanthine biosynthetic process
A	0046632	biological_process	alpha-beta T cell differentiation
A	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
A	0046872	molecular_function	metal ion binding
A	0046936	molecular_function	2'-deoxyadenosine deaminase activity
A	0048286	biological_process	lung alveolus development
A	0048541	biological_process	Peyer's patch development
A	0048566	biological_process	embryonic digestive tract development
A	0050728	biological_process	negative regulation of inflammatory response
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0050852	biological_process	T cell receptor signaling pathway
A	0050862	biological_process	positive regulation of T cell receptor signaling pathway
A	0050870	biological_process	positive regulation of T cell activation
A	0050900	biological_process	leukocyte migration
A	0060169	biological_process	negative regulation of adenosine receptor signaling pathway
A	0060205	cellular_component	cytoplasmic vesicle lumen
A	0060407	biological_process	negative regulation of penile erection
A	0070161	cellular_component	anchoring junction
A	0070242	biological_process	thymocyte apoptotic process
A	0070244	biological_process	negative regulation of thymocyte apoptotic process
A	0070254	biological_process	mucus secretion
A	0070256	biological_process	negative regulation of mucus secretion
A	0140928	biological_process	inhibition of non-skeletal tissue mineralization
C	0000255	biological_process	allantoin metabolic process
C	0001666	biological_process	response to hypoxia
C	0001701	biological_process	in utero embryonic development
C	0001829	biological_process	trophectodermal cell differentiation
C	0001889	biological_process	liver development
C	0001890	biological_process	placenta development
C	0002314	biological_process	germinal center B cell differentiation
C	0002467	biological_process	germinal center formation
C	0002636	biological_process	positive regulation of germinal center formation
C	0002686	biological_process	negative regulation of leukocyte migration
C	0002901	biological_process	mature B cell apoptotic process
C	0002906	biological_process	negative regulation of mature B cell apoptotic process
C	0004000	molecular_function	adenosine deaminase activity
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006154	biological_process	adenosine catabolic process
C	0006157	biological_process	deoxyadenosine catabolic process
C	0006196	biological_process	AMP catabolic process
C	0006915	biological_process	apoptotic process
C	0006939	biological_process	smooth muscle contraction
C	0007155	biological_process	cell adhesion
C	0008270	molecular_function	zinc ion binding
C	0009117	biological_process	nucleotide metabolic process
C	0009168	biological_process	purine ribonucleoside monophosphate biosynthetic process
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010460	biological_process	positive regulation of heart rate
C	0014074	biological_process	response to purine-containing compound
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0019239	molecular_function	deaminase activity
C	0019722	biological_process	calcium-mediated signaling
C	0030217	biological_process	T cell differentiation
C	0030324	biological_process	lung development
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031410	cellular_component	cytoplasmic vesicle
C	0032261	biological_process	purine nucleotide salvage
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0033077	biological_process	T cell differentiation in thymus
C	0033089	biological_process	positive regulation of T cell differentiation in thymus
C	0033632	biological_process	regulation of cell-cell adhesion mediated by integrin
C	0042100	biological_process	B cell proliferation
C	0042110	biological_process	T cell activation
C	0043066	biological_process	negative regulation of apoptotic process
C	0043084	biological_process	penile erection
C	0043605	biological_process	amide catabolic process
C	0044209	biological_process	AMP salvage
C	0045580	biological_process	regulation of T cell differentiation
C	0045582	biological_process	positive regulation of T cell differentiation
C	0045987	biological_process	positive regulation of smooth muscle contraction
C	0046059	biological_process	dAMP catabolic process
C	0046061	biological_process	dATP catabolic process
C	0046085	biological_process	adenosine metabolic process
C	0046101	biological_process	hypoxanthine biosynthetic process
C	0046103	biological_process	inosine biosynthetic process
C	0046111	biological_process	xanthine biosynthetic process
C	0046632	biological_process	alpha-beta T cell differentiation
C	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
C	0046872	molecular_function	metal ion binding
C	0046936	molecular_function	2'-deoxyadenosine deaminase activity
C	0048286	biological_process	lung alveolus development
C	0048541	biological_process	Peyer's patch development
C	0048566	biological_process	embryonic digestive tract development
C	0050728	biological_process	negative regulation of inflammatory response
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0050852	biological_process	T cell receptor signaling pathway
C	0050862	biological_process	positive regulation of T cell receptor signaling pathway
C	0050870	biological_process	positive regulation of T cell activation
C	0050900	biological_process	leukocyte migration
C	0060169	biological_process	negative regulation of adenosine receptor signaling pathway
C	0060205	cellular_component	cytoplasmic vesicle lumen
C	0060407	biological_process	negative regulation of penile erection
C	0070161	cellular_component	anchoring junction
C	0070242	biological_process	thymocyte apoptotic process
C	0070244	biological_process	negative regulation of thymocyte apoptotic process
C	0070254	biological_process	mucus secretion
C	0070256	biological_process	negative regulation of mucus secretion
C	0140928	biological_process	inhibition of non-skeletal tissue mineralization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 902

Chain	Residue
A	HIS17
A	ASP19
A	TYR102
A	SER103
A	LEU106

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 902

Chain	Residue
C	LEU106
C	HOH383
C	HIS17
C	ASP19
C	TYR102
C	SER103

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 401

Chain	Residue
C	HIS15
C	HIS214

Functional Information from PROSITE/UniProt

site_id	PS00485
Number of Residues	7
Details	A_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP

Chain	Residue	Details
A	SER291-PRO297

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000305\|PubMed:8634299, ECO:0000305\|PubMed:9622483

Chain	Residue	Details
A	GLU217
C	GLU217

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:1925539, ECO:0000269\|PubMed:8672487, ECO:0000269\|PubMed:8942668, ECO:0000269\|PubMed:9622483, ECO:0007744\|PDB:1A4L, ECO:0007744\|PDB:1A4M, ECO:0007744\|PDB:1FKW, ECO:0007744\|PDB:1FKX, ECO:0007744\|PDB:1UIO, ECO:0007744\|PDB:1UIP, ECO:0007744\|PDB:2ADA

Chain	Residue	Details
A	HIS15
A	HIS17
A	HIS214
A	ASP295
C	HIS15
C	HIS17
C	HIS214
C	ASP295

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:1925539, ECO:0000269\|PubMed:8672487, ECO:0000269\|PubMed:8942668, ECO:0000269\|PubMed:9622483, ECO:0007744\|PDB:1A4L, ECO:0007744\|PDB:1A4M, ECO:0007744\|PDB:1FKW, ECO:0007744\|PDB:1FKX

Chain	Residue	Details
A	ASP19
C	ASP19

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:1925539, ECO:0000269\|PubMed:8672487, ECO:0000269\|PubMed:8942668, ECO:0000269\|PubMed:9622483, ECO:0007744\|PDB:1A4M, ECO:0007744\|PDB:1FKX, ECO:0007744\|PDB:1UIO, ECO:0007744\|PDB:1UIP, ECO:0007744\|PDB:2ADA

Chain	Residue	Details
A	GLY184
C	GLY184

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:8672487, ECO:0000269\|PubMed:8942668, ECO:0007744\|PDB:1FKW, ECO:0007744\|PDB:1UIP

Chain	Residue	Details
A	ASP296
C	ASP296

site_id	SWS_FT_FI6
Number of Residues	4
Details	SITE: Important for interaction with adenosine receptors and increasing their affinity for agonists => ECO:0000250\|UniProtKB:P00813

Chain	Residue	Details
A	LEU58
A	LEU62
C	LEU58
C	LEU62

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0000269\|PubMed:8942668, ECO:0000269\|PubMed:9622483

Chain	Residue	Details
A	HIS238
C	HIS238

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P00813

Chain	Residue	Details
A	LYS54
A	LYS232
C	LYS54
C	LYS232

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 376

Chain	Residue	Details
A	HIS15	metal ligand
A	HIS17	metal ligand
A	HIS214	metal ligand
A	GLU217	proton shuttle (general acid/base)
A	HIS238	proton shuttle (general acid/base)
A	ASP295	metal ligand, steric role

site_id	MCSA2
Number of Residues	6
Details	M-CSA 376

Chain	Residue	Details
C	HIS15	metal ligand
C	HIS17	metal ligand
C	HIS214	metal ligand
C	GLU217	proton shuttle (general acid/base)
C	HIS238	proton shuttle (general acid/base)
C	ASP295	metal ligand, steric role

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)